(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
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- ₹20719.05 - ₹75894.08
- Product name: (R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
- CAS: 1268524-71-5
- MF: C23H25ClN4O2S
- MW: 456.99
- EINECS:
- MDL Number:MFCD22124456
- Synonyms:(R)-(-)-JQ1 Enantiomer;(R)-(-)-JQ1;(R)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno-[3,2-f][1,2,4]triazolo[4,3-a][1;(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(-)-JQ-1;(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4];JQ-1;JQ1;-JQ1;JQ 1;(6R)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1525
- Product description(-)-JQ1 ≥95% (HPLC)
- Packaging5MG
- Price₹20719.05
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1525
- Product description(-)-JQ1 ≥95% (HPLC)
- Packaging25MG
- Price₹75894.08
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML1525 | (-)-JQ1 ≥95% (HPLC) | 5MG | ₹20719.05 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1525 | (-)-JQ1 ≥95% (HPLC) | 25MG | ₹75894.08 | 2022-06-14 | Buy |
Properties
Boiling point :610.4±65.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :2.05±0.60(Predicted)
form :powder
color :white to beige
InChIKey :DNVXATUJJDPFDM-QGZVFWFLSA-N
Density :1.33
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
pka :2.05±0.60(Predicted)
form :powder
color :white to beige
InChIKey :DNVXATUJJDPFDM-QGZVFWFLSA-N
Safety Information
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Description
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. (±)-JQ1 displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains. The (?)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains, whereas enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively.Related product price
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₹21390.2-75894.08