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4,4'-Bis(4-aminophenoxy)biphenyl

4,4'-Bis(4-aminophenoxy)biphenyl Structure
  • ₹4600 - ₹10100
  • Product name: 4,4'-Bis(4-aminophenoxy)biphenyl
  • CAS: 13080-85-8
  • MF: C24H20N2O2
  • MW: 368.43
  • EINECS:627-298-0
  • MDL Number:MFCD00039151
  • Synonyms:4,4'-(1,1'-BIPHENYL-4,4'-DIYLDIOXY)DIANILINE;4,4'-(P-BIPHENYLENEDIOXY)DIANILINE;4,4-BIS(4-AMINOPHENOXY)BIPHENYL(44BAPOBP) 98%;4,4'-Bis(4-aminophenoxy)biphenyl ,99%;4,4'-(1,1'-Biphenyl-4,4'-diylbisoxy)bisaniline;4,4'-(Biphenyl-4,4'-diylbisoxy)bis(aniline);4,4'-[(1,1'-Biphenyl-4,4'-diyl)bis(oxy)]bisaniline;4,4'-[(4,4'-Biphenylylene)bisoxy]bisaniline
3 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberB1671
  • Product description4,4'-Bis(4-aminophenoxy)biphenyl
  • Packaging5G
  • Price₹4600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB1671
  • Product description4,4'-Bis(4-aminophenoxy)biphenyl
  • Packaging25G
  • Price₹10100
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number476358
  • Product description4,4′-(1,1′-Biphenyl-4,4′-diyldioxy)dianiline 97%
  • Packaging5G
  • Price₹5607.35
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B1671 4,4'-Bis(4-aminophenoxy)biphenyl 5G ₹4600 2022-05-26 Buy
TCI Chemicals (India) B1671 4,4'-Bis(4-aminophenoxy)biphenyl 25G ₹10100 2022-05-26 Buy
Sigma-Aldrich(India) 476358 4,4′-(1,1′-Biphenyl-4,4′-diyldioxy)dianiline 97% 5G ₹5607.35 2022-06-14 Buy

Properties

Melting point :197-200 °C(lit.)
Boiling point :571.4±50.0 °C(Predicted)
Density :1.226±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Room temperature
solubility :DMSO: 74 mg/mL (200.85 mM);;
form :powder to crystal
pka :5.10±0.10(Predicted)
color :White to Gray to Red
InChI :InChI=1S/C24H20N2O2/c25-19-5-13-23(14-6-19)27-21-9-1-17(2-10-21)18-3-11-22(12-4-18)28-24-15-7-20(26)8-16-24/h1-16H,25-26H2
InChIKey :HYDATEKARGDBKU-UHFFFAOYSA-N
SMILES :C1(C2=CC=C(OC3=CC=C(N)C=C3)C=C2)=CC=C(OC2=CC=C(N)C=C2)C=C1
CAS DataBase Reference :13080-85-8(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

4,4'-Bis(4-aminophenoxy)biphenyl is known to be a potent Flk-1 (VEGFR2) inhibitor. It is also known to strongly inhibit Tie-2, Flt-1, Flt-3, Flt-4, Ret, Met (c-Met), and Axl. 4,4'-Bis(4-aminophenoxy)biphenyl has been shown to weakly inhibit Ron, PDGFR, and Flg (FGFR1). At a low concentration in MPNST cells, 4,4'-Bis(4-aminophenoxy)biphenyl has been observed to induce inhibition of inducible and constitutive Met phosphorylation and the resulting downstream signaling, as well as inhibiting HGF-induced MPNST cell invasion and migration. It has also been observed that this product induces marked inhibition of Flk-1 (VEGFR2) and Met phosphorylation in cytokine-stimulated human umbilical vein endothelial cells (HUVECs).

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