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Hydroxy(2-naphthyl)Methanephosphonic Acid

Hydroxy(2-naphthyl)Methanephosphonic Acid Structure
  • ₹0
  • Product name: Hydroxy(2-naphthyl)Methanephosphonic Acid
  • CAS: 132541-52-7
  • MF: C11H11O4P
  • MW: 238.18
  • EINECS:
  • MDL Number:MFCD27943631
  • Synonyms:Hydroxy(2-naphthyl)Methanephosphonic Acid;P-(Hydroxy-2-naphthalenylMethyl)phosphonic Acid;Phosphonic acid, P-(hydroxy-2-naphthalenylmethyl)-;Inhibitor,HNMPA,serine autophosphorylation,tyrosine autophosphorylation,tyrosine kinase,Insulin Receptor,inhibit
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :>180oC(dec.)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO, Methanol
form :White solid.
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Description

HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity. It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 μM in vitro.

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Suppliers and manufacturers

CLEARSYNTH LABS LTD.
Hangzhou MolCore BioPharmatech Co.,Ltd. TargetMol Chemicals Inc. Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd. BOC Sciences Toronto Research Chemicals J & K SCIENTIFIC LTD. Shenzhen Polymeri Biochemical Technology Co., Ltd. ApexBio Technology