2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol
![2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol Structure](/CAS/GIF/1359164-11-6.gif)
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- Product name: 2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol
- CAS: 1359164-11-6
- MF: C26H24F7N3O
- MW: 527.48
- EINECS:
- MDL Number:MFCD25563263
- Synonyms:2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol;SR-2211;2-Fluoro-4'-[[4-(4-pyridinylMethyl)-1-piperazinyl]Methyl]-α,α-bis(trifluoroMethyl)-[1,1'-biphenyl]-4-Methanol (SR 2211);[1,1'-Biphenyl]-4-methanol, 2-fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-;2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol;SR-2211,SR2211
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Properties
Boiling point :552.4±50.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
form :Powder
pka :8.85±0.19(Predicted)
color :Off-white to light brown
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
form :Powder
pka :8.85±0.19(Predicted)
color :Off-white to light brown
Safety Information
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| Signal word: | Danger | ||||||||||||||||
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Description
Retinoic acid receptor-related nuclear receptor γ (RORγ) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis. SR 2211 selectively binds RORγ (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORγ activity (IC50 = 320 nM). It has minimal effects on RORα, LXRα, and FXR activities. SR 2211 significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 μM.More related product prices
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