5-(N,N-HEXAMETHYLENE)-AMILORIDE
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- ₹10402.83 - ₹33514.2
- Product name: 5-(N,N-HEXAMETHYLENE)-AMILORIDE
- CAS: 1428-95-1
- MF: C12H18ClN7O
- MW: 311.77
- EINECS:
- MDL Number:MFCD00069211
- Synonyms:5-(N,N-HEXAMETHYLENE)-AMILORIDE;AMILORIDE,5-(N,N-HEXAMETHYLENE)-;3-AMINO-N-(AMINOIMINOMETHYL)-6-CHLORO-5-(HEXAHYDRO-1H-AZEPIN-1-YL)-PYRAZINE-CARBOXAMIDE;AMILORIDE, 5-(N,N-HEXAMETHYLENE) >93% NA +/H+ ANTIPORTER INH;hma;amipromizide;3-Amino-5-(1-azacycloheptane-1-yl)-6-chloro-N-(aminoiminomethyl)pyrazine-2-carboxamide;3-Amino-5-(hexahydro-1H-azepin-1-yl)-6-chloro-N-(aminoiminomethyl)-2-pyrazinecarboxamide
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 25MG
- 100MG
- ManufacturerSigma-Aldrich(India)
- Product numberA9561
- Product description5-(N,N-Hexamethylene)amiloride
- Packaging25MG
- Price₹10402.83
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberA9561
- Product description5-(N,N-Hexamethylene)amiloride
- Packaging100MG
- Price₹33514.2
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A9561 | 5-(N,N-Hexamethylene)amiloride | 25MG | ₹10402.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A9561 | 5-(N,N-Hexamethylene)amiloride | 100MG | ₹33514.2 | 2022-06-14 | Buy |
Properties
Melting point :224-225 °C
Density :1.63±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 3mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
form :A crystalline solid
pka :8.81±0.46(Predicted)
color :Light yellow to yellow
Density :1.63±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 3mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
form :A crystalline solid
pka :8.81±0.46(Predicted)
color :Light yellow to yellow
Safety Information
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| Signal word: | Danger | ||||||||||
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Description
5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride with diverse biological activities. It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 μM). HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 μM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 μM. It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7. HMA (40 μM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells. HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.Related product price
- Torasemide
₹9000-58390.05 - Amiloride hydrochloride
₹7674.93-43170.1 - 1428-95-1
₹10402.83-33514.2
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