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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE

5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Structure
  • ₹8811.55 - ₹27495.5
  • Product name: 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
  • CAS: 1434-54-4
  • MF: C22H31NO2
  • MW: 341.49
  • EINECS:
  • MDL Number:MFCD00079212
  • Synonyms:5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE;5-pregnen-3B-ol-20-one-16A-carbonitrile;(3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile;(3S,8S,9S,10R,13S,14S,16R,17S)-17-ethanoyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile;pregnenolone-16α-carbonitrile;16α-Cyano-3β-hydroxypregn-5-en-20-one;U-14975;16-alpha)-3-hydroxy-20-oxopregn-5-ene-16-carbonitrile(3-bet
Price3 Properties Safety Information Description
3 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 50MG
  • 100MG
  • 250MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0543
  • Product description5-Pregnen-3β-ol-20-one-16α-carbonitrile ≥97%
  • Packaging250MG
  • Price₹27495.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0543
  • Product description5-Pregnen-3β-ol-20-one-16α-carbonitrile ≥97%
  • Packaging100MG
  • Price₹15068.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0543
  • Product description5-Pregnen-3β-ol-20-one-16α-carbonitrile ≥97%
  • Packaging50MG
  • Price₹8811.55
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P0543 5-Pregnen-3β-ol-20-one-16α-carbonitrile ≥97% 250MG ₹27495.5 2022-06-14 Buy
Sigma-Aldrich(India) P0543 5-Pregnen-3β-ol-20-one-16α-carbonitrile ≥97% 100MG ₹15068.4 2022-06-14 Buy
Sigma-Aldrich(India) P0543 5-Pregnen-3β-ol-20-one-16α-carbonitrile ≥97% 50MG ₹8811.55 2022-06-14 Buy

Properties

Melting point :225-228 °C(Solv: methanol (67-56-1); benzene (71-43-2))
Boiling point :508.5±50.0 °C(Predicted)
Density :1.13±0.1 g/cm3(Predicted)
Flash point :93 °C
storage temp. :2-8°C
solubility :Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
form :White to off-white solid.
pka :14.95±0.70(Predicted)
color :White to off-white
EPA Substance Registry System :Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3.beta.,16.alpha.)- (1434-54-4)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at μM concentrations. It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7α-hydroxylase, regulating both xenobiotic and bile acid homeostasis by enhancing hepatic uptake and biliary excretion. Activation of PXR by 50 mg/kg PCN administered to obesity-prone AKR/J mice has been reported to attenuate the development of high-fat diet-induced obesity and insulin resistance.

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