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ChemicalBook > Product Catalogue >Chemical Reagents >Organic reagents >Amide >N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) Structure
  • ₹11528.63
  • Product name: N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
  • CAS: 1477-57-2
  • MF: C12H20Cl4N2O2
  • MW: 366.11
  • EINECS:216-033-0
  • MDL Number:MFCD00000841
  • Synonyms:FERTILYSIN;N,N'-BIS(DICHLOROACETYL)-1,8-OCTAMETHYLENEDIAMINE;N,N'-OCTA-METHYLENE-BIS[2,2-DICHLOROACETAMIDE];N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE);bisdiamine ;bis-diamine ;n,n’,1,8-octanediylbis(2,2-dichloro-acetamid ;n,n’-bis(dichloroacetyl)-1,8-diaminooctane
Price1 Properties Safety Information Description
1 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML3187
  • Product descriptionWIN 18446 ≥98% (HPLC)
  • Packaging50MG
  • Price₹11528.63
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML3187 WIN 18446 ≥98% (HPLC) 50MG ₹11528.63 2022-06-14 Buy

Properties

Melting point :118-120 °C
Boiling point :530℃
Density :0.726
refractive index :1.6200 (estimate)
Flash point :275℃
storage temp. :Inert atmosphere,2-8°C
solubility :Acetone (Very Slightly), DMSO (Slightly), Methanol (Sparingly, Heated, Sonicated
pka :12.28±0.46(Predicted)
form :Solid
color :White to Off-White
CAS DataBase Reference :1477-57-2

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

WIN 18,446 is a bis-(dichloroacetyl)-diamine which inhibits aldehyde dehydrogenase 1a2, (IC50 = 300 nM), a testes-specific isoform of the enzyme involved in vitamin A metabolism. In this way, WIN 18,446 suppresses the expression of several genes that are regulated by retinoic acid and are necessary for spermatogenesis. As a result, WIN 18,446 may cause infertility in males.

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