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L-N5-(1-IMINOETHYL)ORNITHINE*HYDROCHLORI DE

L-N5-(1-IMINOETHYL)ORNITHINE*HYDROCHLORI DE Structure
  • ₹10143.03 - ₹125786.5
  • Product name: L-N5-(1-IMINOETHYL)ORNITHINE*HYDROCHLORI DE
  • CAS: 150403-88-6
  • MF: C7H15N3O2.ClH
  • MW: 209.675
  • EINECS:
  • MDL Number:MFCD00153817
  • Synonyms:L-NIO hydrochloride, L-Ornithine ω-acetamidine hydrochloride;L-Ornithine ψ-acetamidine hydrochloride;N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO);Nδ-(IMinoethyl)-L-ornithine;(S)-5-Acetimidamido-2-aminopentanoic acid hydrochloride
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberI134
  • Product descriptionL-N5-(1-Iminoethyl)ornithine hydrochloride ≥95% (HPLC)
  • Packaging1MG
  • Price₹10143.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberI134
  • Product descriptionL-N5-(1-Iminoethyl)ornithine hydrochloride ≥95% (HPLC)
  • Packaging5MG
  • Price₹36696.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberI134
  • Product descriptionL-N5-(1-Iminoethyl)ornithine hydrochloride ≥95% (HPLC)
  • Packaging25MG
  • Price₹125786.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) I134 L-N5-(1-Iminoethyl)ornithine hydrochloride ≥95% (HPLC) 1MG ₹10143.03 2022-06-14 Buy
Sigma-Aldrich(India) I134 L-N5-(1-Iminoethyl)ornithine hydrochloride ≥95% (HPLC) 5MG ₹36696.75 2022-06-14 Buy
Sigma-Aldrich(India) I134 L-N5-(1-Iminoethyl)ornithine hydrochloride ≥95% (HPLC) 25MG ₹125786.5 2022-06-14 Buy

Properties

Melting point :225-226°C
storage temp. :Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility :H2O: soluble2mg/mL, clear (warmed)
form :powder
color :white to beige
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

N(5)-(1-Iminoethyl)-L-ornithine HCl (L-NIO), is an inhibitor of NOS3 (nitric oxide synthase) in the vascular endothelium that can halt endothelium-dependent relaxation induced by acteylcholine and cause endothelium-dependent contraction in aortic rings. Mechanistic studies have noted that L-NIO inhibits Ca2+-dependent NOS3 (eNOS). The same experiment on rat aorta has shown L-NIO to display a capacity to induce a dose-dependent increase in mean systemic arterial blood pressure. In addition, research has shown L-NIO to be the most potent inhibitor of the neutrophil and J774 enzymes compared to its analogues L-NMMA, L-NAME, and L-NNA.

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