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4-(di(1H-indol-3-yl)Methyl)phenol

4-(di(1H-indol-3-yl)Methyl)phenol Structure
  • ₹0
  • Product name: 4-(di(1H-indol-3-yl)Methyl)phenol
  • CAS: 151358-47-3
  • MF: C23H18N2O
  • MW: 338.4
  • EINECS:-0
  • MDL Number:MFCD03723253
  • Synonyms:4-(di(1H-indol-3-yl)Methyl)phenol;DIM-C-pPhOH;4-[bis(1H-indol-3-yl)methyl]phenol;C-DIM8;1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane;DIM-C-pPhOH(CDIM8);Phenol, 4-(di-1H-indol-3-ylmethyl)-;inhibit,receptor,Inhibitor,β1-integrin,mTOR,cancer,DIMCpPhOH,signaling,nuclear,xenografts,Apoptosis,DIM C pPhOH,stress
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :122-124 °C
Boiling point :610.2±50.0 °C(Predicted)
Density :1.321±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (35 mg/ml); ethanol (35 mg/ml)
form :solid
pka :9.98±0.26(Predicted)
color :Pink
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

C-DIM 8 (151358-47-3) is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancreatic cancer cells.2 C-DIM 8 mimics the effect of Nur77 knockdown in non-small-cell lung cancer A549 and H460 cells, inhibiting cell growth and inducing apoptosis which was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling.3 Inhibits the expression of β1- and β3-integrin and blocks integrin-dependent breast cancer cell migration.4 Decreases expression of the histone methyltransferase G9A (EHMT2) in a variety of cancer cell lines.5

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Suppliers and manufacturers

A.J Chemicals
ATK CHEMICAL COMPANY LIMITED
InvivoChem
TargetMol Chemicals Inc.
Aladdin Scientific
Amadis Chemical Company Limited Beijing Bolide Biotechnology Co., Ltd. Shanghai Haoyang Biological Technology Co., Ltd. Shanghai Minmin Biotechnology Co., Ltd. Xiamen Huijia Biological Technology Co., Ltd.