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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Antiarrhythmics Drugs >(+/-)-Verapamil hydrochloride

(+/-)-Verapamil hydrochloride

(+/-)-Verapamil hydrochloride Structure
  • ₹3697.4 - ₹74551.78
  • Product name: (+/-)-Verapamil hydrochloride
  • CAS: 152-11-4
  • MF: C27H39ClN2O4
  • MW: 491.06
  • EINECS:205-800-5
  • MDL Number:MFCD00069355
  • Synonyms:Valeronitrile, 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl-, monohydrochloride;Hormitol;Magotiron;Rositol;(#1)-Verapamil hydrochloride;α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrilehydrochloride;Verapamil Hydrochloride (200 mg);2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl )ethyl](methyl)amino]-2-isopropylpentanenitrileHCl
8 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 100MG
  • 1ML
  • 1G
  • 5G
  • 10G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberV0118
  • Product descriptionVerapamil Hydrochloride
  • Packaging5G
  • Price₹6600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberV0118
  • Product descriptionVerapamil Hydrochloride
  • Packaging25G
  • Price₹13000
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV-002
  • Product descriptionVerapamil hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹3697.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number676777
  • Product description(±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells.
  • Packaging100MG
  • Price₹8210
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1131
  • Product description(±)-Verapamil hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹8995.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV4629
  • Product description(±)-Verapamil hydrochloride ≥99% (titration), powder
  • Packaging1G
  • Price₹12935.88
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV4629
  • Product description(±)-Verapamil hydrochloride ≥99% (titration), powder
  • Packaging5G
  • Price₹41860.28
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberV4629
  • Product description(±)-Verapamil hydrochloride ≥99% (titration), powder
  • Packaging10G
  • Price₹74551.78
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) V0118 Verapamil Hydrochloride 5G ₹6600 2022-05-26 Buy
TCI Chemicals (India) V0118 Verapamil Hydrochloride 25G ₹13000 2022-05-26 Buy
Sigma-Aldrich(India) V-002 Verapamil hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹3697.4 2022-06-14 Buy
Sigma-Aldrich(India) 676777 (±)-Verapamil, Hydrochloride - CAS 152-11-4 - Calbiochem A papaverine derivative that blocks Ca2+ channels (principally the L-type) in smooth and cardiac muscle cells. 100MG ₹8210 2022-06-14 Buy
Sigma-Aldrich(India) PHR1131 (±)-Verapamil hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹8995.58 2022-06-14 Buy
Sigma-Aldrich(India) V4629 (±)-Verapamil hydrochloride ≥99% (titration), powder 1G ₹12935.88 2022-06-14 Buy
Sigma-Aldrich(India) V4629 (±)-Verapamil hydrochloride ≥99% (titration), powder 5G ₹41860.28 2022-06-14 Buy
Sigma-Aldrich(India) V4629 (±)-Verapamil hydrochloride ≥99% (titration), powder 10G ₹74551.78 2022-06-14 Buy

Properties

Melting point :142 °C (dec.)(lit.)
Density :1.0596 (rough estimate)
refractive index :1.6290 (estimate)
Flash point :9℃
storage temp. :2-8°C
solubility :H2O: >30 mg/mL
form :solid
pka :8.6(at 25℃)
color :white
Water Solubility :soluble
Merck :14,9950
BRN :3647093
BCS Class :2
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference :152-11-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P391 Collect spillage. Hazardous to the aquatic environment
P405 Store locked up.

Description

Verapamil is the prototypical blocker of L-type calcium channels that produces excitation-contraction uncoupling in cardiac muscle by preventing the slow-inward current of calcium ions. Verapamil can also block calcium fluxes in vascular smooth muscle. It has both peripheral and coronary vasodilator effects (IC50 = 0.38 μM in guinea pig aortic strip) and has been used to control hypertension, angina, cardiac arrhythmia, and vascular headaches. Verapamil has also been used in cell biology as an inhibitor of drug efflux pump proteins such as P-glycoprotein, which are often over-expressed in certain tumor cell lines.

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