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15(S)-Latanoprost

15(S)-Latanoprost Structure
  • ₹56787.95
  • Product name: 15(S)-Latanoprost
  • CAS: 145773-22-4
  • MF: C26H40O5
  • MW: 432.59
  • EINECS:687-773-3
  • MDL Number:MFCD04974500
  • Synonyms:15(S)-LATANOPROST;15(S)-LATANOPROST ISOPROPYL ESTER;15-EPI LATANOPROST ISOPROPYL ESTER;9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID ISOPROPYL ESTER;(5Z,9ALPHA,11ALPHA,15S)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OATE ISOPROPYL ESTER;(Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoic acid isopropyl ester;15-epi Latanoprost;Latanoprost Related Compound B (25 mg) (Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3S)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoate)
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Brand

  • Sigma-Aldrich(India)

Package

  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR3022
  • Product descriptionLatanoprost Related Compound B pharmaceutical secondary standard, certified reference material
  • Packaging50MG
  • Price₹56787.95
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PHR3022 Latanoprost Related Compound B pharmaceutical secondary standard, certified reference material 50MG ₹56787.95 2022-06-14 Buy

Properties

Boiling point :583.8±50.0 °C(Predicted)
Density :1.093±0.06 g/cm3(Predicted)
Flash point :-16 °C
storage temp. :−20°C
solubility :DMF: 100 mg/ml; DMSO: 100 mg/ml; DMSO:PBS (1:12): 80 μg/ml; Ethanol: 100 mg/ml
form :Oil
pka :14.84±0.70(Predicted)
color :Colourless
InChIKey :GGXICVAJURFBLW-SCTZCWPJSA-N

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys. 15(S)-Latanoprost is a potential impurity in most commercial preparations of the latanoprost bulk drug product.

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