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ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Bulk Drug Intermediates >4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Structure
  • ₹4400 - ₹12000
  • Product name: 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
  • CAS: 162012-67-1
  • MF: C14H7ClF2N4O2
  • MW: 336.68
  • EINECS:-0
  • MDL Number:MFCD09998825
  • Synonyms:4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-;4-(3-chloro-4-fiuoro-phen...;N-(3-chloro-4-fluorophenyl)-N-(7-fluoro-6-nitroquinazolin-4-yl)acetaMide;(3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine;Afatinib intermediate A;3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl);N-(3-chloro-4-fluorophenyl)-7-fiuoro-6-nitro-4-quinazolinaMine;N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • TCI Chemicals (India)

Package

  • 5G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberC3276
  • Product descriptionN-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
  • Packaging5G
  • Price₹4400
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC3276
  • Product descriptionN-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
  • Packaging25G
  • Price₹12000
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C3276 N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine 5G ₹4400 2022-05-26 Buy
TCI Chemicals (India) C3276 N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine 25G ₹12000 2022-05-26 Buy

Properties

Melting point :242-244℃
Boiling point :489℃
Density :1.616
Flash point :249℃
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly, Sonicated)
form :Solid
pka :5.07±0.70(Predicted)
color :Yellow to Dark Yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

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4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- 162012-69-3 Afatinib (BIBW 2992) 86087-23-2 BIBW2992 DiMaleate Afatinib (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine trans-4-Dimethylaminocrotonic acid hydrochloride 7-Fluoro-4-quinazolone TRANS-4-AMINOCROTONIC ACID

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Suppliers and manufacturers

Molkem Chemicals VGS SYNTHESIS PRIVATE LIMITED Vibrant Life Sciences Lakshmi Farmachem S S Arofine Accrete Pharmaceuticals Private Limited Myosynth Laboratories Pvt Ltd CLEARSYNTH LABS LTD. A.J Chemicals TCI Chemicals (India) Pvt. Ltd.