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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Tinib Antineoplastic drugs >Afatinib

Afatinib

Afatinib Structure
  • ₹3500 - ₹14900
  • Product name: Afatinib
  • CAS: 850140-72-6
  • MF: C24H25ClFN5O3
  • MW: 485.94
  • EINECS:
  • MDL Number:MFCD12407405
  • Synonyms:Afatinib;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;4-[(3-chloro-4-fluorophenyl)aMino]-6-{[4-(N,N-diMethylaMino)-1-oxo-2-buten-1-yl]aMino}-7-((S)-tetrahydrofuran-3-yloxy)-quinazoline;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-;(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dime;Afatinib API;Afatinib(BIBW2992MA2);GILOTRIF(AFATINIB)
2 prices
Selected condition:

Brand

  • TCI Chemicals (India)

Package

  • 50MG
  • 250MG
  • ManufacturerTCI Chemicals (India)
  • Product numberA2870
  • Product descriptionAfatinib
  • Packaging50MG
  • Price₹3500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA2870
  • Product descriptionAfatinib
  • Packaging250MG
  • Price₹14900
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) A2870 Afatinib 50MG ₹3500 2022-05-26 Buy
TCI Chemicals (India) A2870 Afatinib 250MG ₹14900 2022-05-26 Buy

Properties

Melting point :102 °C
Boiling point :676.9±55.0 °C(Predicted)
Density :1.380
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form :Yellow powder.
pka :11.79±0.43(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.

Description

Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2 (IC50?= 14 nM).

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