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4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE

4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE Structure
  • ₹0
  • Product name: 4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
  • CAS: 162012-70-6
  • MF: C8H3ClFN3O2
  • MW: 227.58
  • EINECS:-0
  • MDL Number:MFCD08063159
  • Synonyms:4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE;4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE###162012-70-6;4-chloro-6-nitro-7-fluoro-quinazoline;Afatinib impurity 6: 4-chloro-7fluoro-6-nitroquinazoline;Quinazoline, 4-chloro-7-fluoro-6-nitro-
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :395℃
Density :1.649
Flash point :193℃
storage temp. :Sealed in dry,Store in freezer, under -20°C
pka :0.53±0.70(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

4-Chloro-7-fluoro-6-nitroquinazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

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