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ChemicalBook > Product Catalogue >Biochemical Engineering >nucleic acid drugs >6-METHYLAMINOPURINE 9-RIBOFURANOSIDE

6-METHYLAMINOPURINE 9-RIBOFURANOSIDE

6-METHYLAMINOPURINE 9-RIBOFURANOSIDE Structure
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  • Product name: 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
  • CAS: 1867-73-8
  • MF: C11H15N5O4
  • MW: 281.27
  • EINECS:200-001-2
  • MDL Number:MFCD00005739
  • Synonyms:NSC-29409;6-Methylaminopurine D-riboside;6-Methylaminopurine ribonucleoside;6-Methylaminopurinosine;Adenosine, N-methyl-;(2R,3S,4R,5R)-2-(HydroxyMethyl)-5-(6-(MethylaMino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol;N6-methyladenosine (m6A);N6-Me-rA
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Properties

Melting point :172 °C
Boiling point :649.1±65.0 °C(Predicted)
Density :1.85±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form :Powder
pka :13.12±0.70(Predicted)
color :White to off-white
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

N6-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.

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