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ChemicalBook > Product Catalogue >Biochemical Engineering >Nucleoside drugs >Nucleoside Intermediates >2-Chloroadenosine

2-Chloroadenosine

2-Chloroadenosine Structure
  • ₹3100 - ₹392049.03
  • Product name: 2-Chloroadenosine
  • CAS: 146-77-0
  • MF: C10H12ClN5O4
  • MW: 301.69
  • EINECS:205-678-3
  • MDL Number:MFCD00005734
  • Synonyms:2-Chloroadenosine Hydrate;2-CHLOROADENOSINE (6-AMINO-2-CHLOROPURINE RIBOSIDE);9-[3α,4α-Dihydroxy-5β-(hydroxymethyl)tetrahydrofuran-2β-yl]-2-chloro-9H-purine-6-amine;Antibiotic AT-265B;AT-265B;CI-ADO;CADO;6-Amino-2-chloropuri
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 100MG
  • 250MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberC2192
  • Product description2-Chloroadenosine
  • Packaging100MG
  • Price₹3100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC2192
  • Product description2-Chloroadenosine
  • Packaging1G
  • Price₹6400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC5134
  • Product description2-Chloroadenosine
  • Packaging10MG
  • Price₹10792.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC5134
  • Product description2-Chloroadenosine
  • Packaging50MG
  • Price₹36956.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC5134
  • Product description2-Chloroadenosine
  • Packaging250MG
  • Price₹126933.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC5134
  • Product description2-Chloroadenosine
  • Packaging1G
  • Price₹392049.03
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C2192 2-Chloroadenosine 100MG ₹3100 2022-05-26 Buy
TCI Chemicals (India) C2192 2-Chloroadenosine 1G ₹6400 2022-05-26 Buy
Sigma-Aldrich(India) C5134 2-Chloroadenosine 10MG ₹10792.53 2022-06-14 Buy
Sigma-Aldrich(India) C5134 2-Chloroadenosine 50MG ₹36956.55 2022-06-14 Buy
Sigma-Aldrich(India) C5134 2-Chloroadenosine 250MG ₹126933.95 2022-06-14 Buy
Sigma-Aldrich(India) C5134 2-Chloroadenosine 1G ₹392049.03 2022-06-14 Buy

Properties

Melting point :162 °C
Boiling point :591.8±60.0 °C(Predicted)
Density :1.8359 (rough estimate)
refractive index :-50 ° (C=0.1, H2O)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: 10 mg/mL, clear, colorless
form :Solid
pka :13.05±0.70(Predicted)
color :White to Off-White
Water Solubility :Soluble in water.
BRN :43957
InChIKey :BIXYYZIIJIXVFW-UUOKFMHZSA-N
CAS DataBase Reference :146-77-0(CAS DataBase Reference)
NIST Chemistry Reference :Adenosine, 2-chloro-(146-77-0)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively. CADO has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures. It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats.

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