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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Proline derivatives >1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Structure
  • ₹6400 - ₹18700
  • Product name: 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
  • CAS: 203866-14-2
  • MF: C10H16FNO4
  • MW: 233.24
  • EINECS:
  • MDL Number:MFCD06796085
  • Synonyms:N-T-BOC-TRANS-4-FLUORO-L-PROLINE;N-(TERT-BUTOXYCARBONYL)-(2S,4R)-4-FLUOROPROLINE;BOC-TRANS-4-FLUORO-L-PROLINE;(2S,4R)-N-Boc-trans-4-Fluoro-L-Proline;(2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid, N4-BOC protected;trans-4-Fluoro-L-proline, N-BOC protected;(2S,4R)-Boc-4-fluoro-pyrrolidine-2-carboxylic acid;(2R,4S)-N-BOC-4-FLUORO-D-PROLINE
3 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 200MG
  • 500MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberB3177
  • Product description(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid min. 96.0 %
  • Packaging200MG
  • Price₹6400
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB3177
  • Product description(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid min. 96.0 %
  • Packaging1G
  • Price₹18700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number687332
  • Product descriptionN-Boc-trans-4-fluoro-L-proline 97%
  • Packaging500MG
  • Price₹8530.1
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B3177 (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid min. 96.0 % 200MG ₹6400 2022-05-26 Buy
TCI Chemicals (India) B3177 (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid min. 96.0 % 1G ₹18700 2022-05-26 Buy
Sigma-Aldrich(India) 687332 N-Boc-trans-4-fluoro-L-proline 97% 500MG ₹8530.1 2022-06-14 Buy

Properties

Melting point :115-119°C
Boiling point :346.0±42.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
refractive index :-69 ° (C=1, MeOH)
storage temp. :Inert atmosphere,Room Temperature
solubility :soluble in Methanol
form :powder to crystal
pka :3.53±0.40(Predicted)
color :White to Almost white
optical activity :[α]22/D -65.0±5°, c = 1 in chloroform
InChIKey :YGWZXQOYEBWUTH-RQJHMYQMSA-N
CAS DataBase Reference :203866-14-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

N-Boc-trans-4-fluoro-L-proline is a useful synthetic intermediate. It is used to prepare potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrrolotriazines derivatives as pan-Aurora kinase inhibitors and anti-tumor agents.

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