GLY-PHE BETA-NAPHTHYLAMIDE
- ₹0
- Product name: GLY-PHE BETA-NAPHTHYLAMIDE
- CAS: 21438-66-4
- MF: C21H21N3O2
- MW: 347.41
- EINECS:
- MDL Number:MFCD00021597
- Synonyms:glycylphenylalanine2-naphthylamide ;GLY-PHE BETA-NAPHTHYLAMIDE;H-GLY-PHE-BETA-NA;gly-phe B-naphthylamide;H-Gly-Phe-bNA;glycyl-L-phenylalanine 2-naphthylamide;gly-phe β-naphthylamide;(S)-N-(2-(2-Aminoacetamido)-3-phenylpropanoyl)-2-naphthamide
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Properties
Boiling point :692.4±55.0 °C(Predicted)
Density :1.254±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :Soluble in 100mg in 200µl DMSO.
form :crystalline
pka :13.62±0.46(Predicted)
color :White to off-white
Density :1.254±0.06 g/cm3(Predicted)
storage temp. :−20°C
solubility :Soluble in 100mg in 200µl DMSO.
form :crystalline
pka :13.62±0.46(Predicted)
color :White to off-white
Safety Information
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Signal word: | Warning | ||||||||||||||
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Description
Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates. Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases and proapoptotic proteins. Gly-Phe-β-naphthylamide is a substrate of cathepsin C that accumulates within the lysosome. Hydrolysis by cathepsin C degrades Gly-Phe-β-naphthylamide into fragments that do not easily diffuse through the lysosomal membrane, leading to a loss of lysosome membrane integrity. This compound has been used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C. At 50 μM, Gly-Phe-β-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8.Related product price
- GLY-PHE P-NITROANILIDE
₹13044.13-106009.23 - 103213-34-9
₹16659.68-53616.23 - H-GLY-PNA
₹23739.23
Suppliers and manufacturers
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