3-CYANO-7-ETHOXYCOUMARIN
- ₹26695.5 - ₹48040.8
- Product name: 3-CYANO-7-ETHOXYCOUMARIN
- CAS: 117620-77-6
- MF: C12H9NO3
- MW: 215.2
- EINECS:200-562-0
- MDL Number:MFCD00467359
- Synonyms:7-Ethoxy-2-oxo-2H-chroMene-3-carbonitrile;7-ETHOXYCOUMARIN-3-CARBONITRILE;3-CYANO-7-ETHOXYCOUMARIN;2H-1-Benzopyran-3-carbonitrile,7-ethoxy-2-oxo-(9CI);3-Cyano-7-ethoxycoumarin [7-Ethoxycoumarin-3-carbonitrile] *Cytochrome P450 Substrate*;7-Ethoxy-2-oxo-2H-1-benzopyran-3-carbonitrile;CEC [3-Cyano-7-ethoxycoumarin] *CAS 117620-77-6*;CEC [3-Cyano-7-ethoxycoumarin
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product numberUC455
- Product description3-Cyano-7-ethoxycoumarin ≥97% (HPLC)
- Packaging5MG
- Price₹26695.5
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberUC455
- Product description3-Cyano-7-ethoxycoumarin ≥97% (HPLC)
- Packaging10MG
- Price₹48040.8
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | UC455 | 3-Cyano-7-ethoxycoumarin ≥97% (HPLC) | 5MG | ₹26695.5 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | UC455 | 3-Cyano-7-ethoxycoumarin ≥97% (HPLC) | 10MG | ₹48040.8 | 2022-06-14 | Buy |
Properties
Melting point :210-212°C
Boiling point :396.8±42.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble
form :Solid
color :yellow to orange
λmax :356 nm (Buffer pH7); 355 nm(MeOH)
Biological Applications :As a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.
Boiling point :396.8±42.0 °C(Predicted)
Density :1.29±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble
form :Solid
color :yellow to orange
λmax :356 nm (Buffer pH7); 355 nm(MeOH)
Biological Applications :As a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.
Safety Information
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Description
This reagent is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases. The product of the reaction is the fluorescent compound 3-cyano-7-hydroxycoumarin (Product No. C 2737). This property has been utilized to determine the activity of CYP1A by measuring the rate of dealkylation of 3-Cyano-7-ethoxycoumarin to this fluorescent product. Fluorescence of 3-cyano-7-hydroxycoumarin occurs at neutral pH with excitation and emission at 408 and 450 nm, respectively. Fluorescent reaction product detection is at least 50-fold more sensitive than that of the product of alkyl resorufin oxidation because of greater rate of turnover of 3-Cyano-7-ethoxycoumarin. The ability to continuously monitor the enzyme reaction at pH 7 is derived from the lower pKa of the 3-cyano-7- hydroxycoumarin product compared to that for 7-ethoxycoumarin. 3-Cyano-7-ethoxycoumarin is a suitable substrate for three of the five principal cytochrome P450 drug metabolizing enzymes, CYP1A1, CYP1A2, CYP2C9, and CYP2C19. It has been used to measure cytochrome P450 mixed-function monooxygenases in rat hepatic microsomal preparations as well as in isolated rat hepatocytes. It was part of a study to examine the expression of CYP2B6 in human liver microsomes, and has been used to characterize Clara and type II cells from rat lung.More related product prices
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