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5-NITROSO-8-HYDROXYQUINOLINE

5-NITROSO-8-HYDROXYQUINOLINE Structure
  • ₹0
  • Product name: 5-NITROSO-8-HYDROXYQUINOLINE
  • CAS: 3565-26-2
  • MF: C9H6N2O2
  • MW: 174.16
  • EINECS:222-650-6
  • MDL Number:MFCD00041862
  • Synonyms:8-HYDROXY-5-NITROSOQUINOLINE;NSC 3852;5-Nitroso-8-cinnolinol;5-nitroso-8-quinolino ;8-Quinolinol, 5-nitroso-;Hydron III;hydroniii ;RMH-79
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :245 °C
Boiling point :305.12°C (rough estimate)
Density :1.40
refractive index :1.5651 (estimate)
storage temp. :Store at RT
solubility :insoluble in EtOH; insoluble in H2O; ≥7.35 mg/mL in DMSO
form :solid
color :Needles from EtOH
CAS DataBase Reference :3565-26-2(CAS DataBase Reference)
EPA Substance Registry System :8-Quinolinol, 5-nitroso- (3565-26-2)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

5-Nitroso-8-quinolinol is a chemically unique HDAC inhibitor that harbors a different Zn2+ chelation motif compared to SAHA. As an antitumor agent, 10 μM 5-nitroso-8-quinolinol can induce oxidative stress contributing to apoptosis and differentiation in MCF-7 breast cancer cells. Additionally, 5-nitroso-8-quinolinol inhibits T. gondii tachyzoite propagation in human fibroblasts with an EC50 value of 80 nM and inhibits P. falciparum growth in human red blood cells with an EC50 value of 1.3 μM.

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5-NITROSO-8-HYDROXYQUINOLINE

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Suppliers and manufacturers

career henan chemical co
5-nitrosoquinolin-8-ol
₹1.00 /1KG
5-nitrosoquinolin-8-ol CAS:3565-26-2
Neugen Labs CLEARSYNTH LABS LTD.
Capot Chemical Co.,Ltd.
Zhejiang ZETian Fine Chemicals Co. LTD
CONIER CHEM AND PHARMA LIMITED
Dayang Chem (Hangzhou) Co.,Ltd.
LEAP CHEM CO., LTD.
Coresyn Pharmatech Co., Ltd.
TargetMol Chemicals Inc.