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N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE

N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE Structure
  • ₹20156.15 - ₹85885.55
  • Product name: N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE
  • CAS: 431898-65-6
  • MF: C17H11ClN4O
  • MW: 322.75
  • EINECS:
  • MDL Number:MFCD18089825
  • Synonyms:N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide;IKK Inhibitor X;PS 1145;N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE;PS-1145 DIHYDROCHLORIDE;PS 1145;PS1145;CS-2600;3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberP6624
  • Product descriptionPS-1145 dihydrochloride ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹20156.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP6624
  • Product descriptionPS-1145 dihydrochloride ≥98% (HPLC), solid
  • Packaging25MG
  • Price₹85885.55
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P6624 PS-1145 dihydrochloride ≥98% (HPLC), solid 5MG ₹20156.15 2022-06-14 Buy
Sigma-Aldrich(India) P6624 PS-1145 dihydrochloride ≥98% (HPLC), solid 25MG ₹85885.55 2022-06-14 Buy

Properties

Boiling point :511.0±50.0 °C(Predicted)
Density :1.513±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >3mg/mL at ~60°C, clear (with warming for 2 minutes)
pka :11.75±0.43(Predicted)
form :solid
color :yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Nuclear factor-κB (NF-κB) is a protein complex which modulates gene transcription relevant to cellular responses to inflammation, stress, infection, and other factors. The inhibitor of NF-κB kinase β (IKKβ), in complex with IKKα and IKKγ, phosphorylates inhibitor of NF-κB A and B (IκA and IκB) and other proteins involved in NF-κB signaling, and thus plays a central regulatory role. PS-1145 is a potent inhibitor of IKKβ (IC50 = 88-100 nM). Through this action, it is used to elucidate roles for NF-κB both in cells and in vivo.

Suppliers and manufacturers

career henan chemical co
N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide
₹9.80 /1KG
N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide CAS:431898-65-6
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