(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
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- ₹0
- Product name: (+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST
- CAS: 5652-28-8
- MF: C3H8NO5P
- MW: 169.07
- EINECS:
- MDL Number:MFCD00014350
- Synonyms:(+-)-2-AMINO-3-PHOSPHONOPROPIONIC ACID ( AP-3)NMDA ANTAGONIST;2-Amino-3-phosphonopropionic acid;2-AP3;Alanine, 3-phosphono-
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Properties
Boiling point :481.6±55.0 °C(Predicted)
Density :1.763±0.06 g/cm3(Predicted)
solubility :PBS (pH 7.2): 2 mg/ml
form :White powder.
pka :1.22±0.10(Predicted)
color :White to off-white
Density :1.763±0.06 g/cm3(Predicted)
solubility :PBS (pH 7.2): 2 mg/ml
form :White powder.
pka :1.22±0.10(Predicted)
color :White to off-white
Safety Information
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Description
Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms. DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 μM and an IC50 value of 1mM for rat mGluR1α when challenged with glutamate. DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex. At concentrations from 10-300 μM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson’s disease, and the increased activity of mGluR implicated in fragile X syndrome.Related product price
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