1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE
![1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Structure](/CAS/GIF/566-76-7.gif)
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- ₹43437.8
- Product name: 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE
- CAS: 566-76-7
- MF: C18H22O3
- MW: 286.37
- EINECS:
- MDL Number:MFCD00870436
- Synonyms:1,3,5(10)-ESTRATRIEN-3,16-ALPHA-DIOL-17-ONE;3,16ALPHA-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE;(16R)-3,16α-Dihydroxy-1,3,5(10)-estratriene-17-one;16α-OHE1;3,16α-Dihydroxy-1,3,5(10)-estratrien-17-one;C05300;(16α)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one;Estra-1,3,5(10)-triene-3,16α-diol-17-one
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1ML
- ManufacturerSigma-Aldrich(India)
- Product numberH-126
- Product description16α-Hydroxyestrone 100?μg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant?
- Packaging1ML
- Price₹43437.8
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H-126 | 16α-Hydroxyestrone 100?μg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant? | 1ML | ₹43437.8 | 2022-06-14 | Buy |
Properties
Melting point :209-211°C
Boiling point :493.2±45.0 °C(Predicted)
Density :1.249±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form :Solid
pka :10.23±0.60(Predicted)
color :White to Light Beige
Boiling point :493.2±45.0 °C(Predicted)
Density :1.249±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form :Solid
pka :10.23±0.60(Predicted)
color :White to Light Beige
Safety Information
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Description
The naturally-occurring estrogens are estrone (E1, ), estradiol (E2, ), and estriol (E3, ). 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE1 is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E1, 16α-OHE1 binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE1 are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive.More related product prices
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