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DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE

DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE Structure
  • ₹11961.63 - ₹48106.3
  • Product name: DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
  • CAS: 64005-90-9
  • MF: C22H18N2O8
  • MW: 438.39
  • EINECS:
  • MDL Number:MFCD00333607
  • Synonyms:PIB;DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE;WNKQGFNIIHNGQM-UHFFFAOYSA-N;PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem;Benzo[lmn][3,8]phenanthroline-2,7-diacetic acid, 1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-, 2,7-diethyl ester;PiB >=98% (HPLC);PPIase-Parvulin inhibitor,Inhibitor,PPIase Parvulin Inhibitor,PPIaseParvulin Inhibitor,inhibit;diethyl 2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)diacetate
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberB7688
  • Product descriptionPiB ≥98% (HPLC)
  • Packaging5MG
  • Price₹11961.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB7688
  • Product descriptionPiB ≥98% (HPLC)
  • Packaging25MG
  • Price₹48106.3
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) B7688 PiB ≥98% (HPLC) 5MG ₹11961.63 2022-06-14 Buy
Sigma-Aldrich(India) B7688 PiB ≥98% (HPLC) 25MG ₹48106.3 2022-06-14 Buy

Properties

storage temp. :2-8°C
solubility :DMSO: soluble1-2mg/mL (warmed)
form :Brownish solid
color :white to light brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Peptidyl-prolyl isomerases (PPIases) assist in the folding of newly-synthesized proteins, regulating the stability, localization, and activity of mature proteins. PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases Pin1 and Pin4 (IC50s = 1.5 and 1.0 μM, respectively), interacting with the PPIase domain. It blocks the proliferation of cancer cells that overexpress Pin1 and Pin4 (IC50 range = 2-5 μM), and similarly inhibits wild type mouse embryonic fibroblasts (MEFs) but not Pin1-/- MEFs. PPIase-Parvulin Inhibitor does not inhibit topoisomerase I or bind DNA. Also referred to as PiB, this compound is commonly used to determine the role of Pin1 in regulating various substrates and cellular functions.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Aladdin Scientific Nantong Hanfang Biotechnology Co. , Ltd. Cayman Chemical Company Shanghai Yifei Biotechnology Co. , Ltd. Beijing Yusheng Chemical Co., Ltd. Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. Shanghai Rechem science Co., Ltd. EMD Biosciences, Inc. Riedel-de Haen AG