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L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID

L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID Structure
  • ₹6895.53 - ₹22407.75
  • Product name: L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID
  • CAS: 64769-66-0
  • MF: C6H9NO4
  • MW: 159.14
  • EINECS:
  • MDL Number:MFCD00153866
  • Synonyms:L-TRANS-4-CARBOXY-L-PROLINE;L-TRANS-PYRROLIDINE-2,4-DICARBOXYLIC ACID;L-TRANS-2,4-PDC;TRANS-4-CARBOXY-L-PROLINE;2,4-Pyrrolidinedicarboxylicacid,(2S,4R)-(9CI);Zinc03796127;(2S,4R)-pyrrolidine-2,4-dicarboxylic acid;(2S,4R)-2,4-Pyrrolidinedicarboxylic acid
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 2MG
  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberP7575
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98%
  • Packaging10MG
  • Price₹22407.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP7575
  • Product descriptionL-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98%
  • Packaging2MG
  • Price₹6895.53
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P7575 L-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98% 10MG ₹22407.75 2022-06-14 Buy
Sigma-Aldrich(India) P7575 L-trans-Pyrrolidine-2,4-dicarboxylic acid ≥98% 2MG ₹6895.53 2022-06-14 Buy

Properties

Melting point :214-217oC
storage temp. :Store at RT
solubility :Water (Slightly)
form :White solid.
color :White
Water Solubility :Soluble to 100 mM in water

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) is a glutamate uptake blocker, serving as a "conformer mimic" of the glutamate molecule as recognized by EAAT (excitatory amino acid transporter) proteins. L-trans-PDC is demonstrated to increase extracellular glutamate concentration without affecting extracellular GABA levels. Blockade of glutamate uptake by L-trans-PDC has a correlated effect of inducing neuronal Ca2+ influx and massive NMDA receptor-mediated neuronal death. Specificity of L-trans-PDC for the EAAT protein over other glutamate-recognizing loci indicates a particular structural requirement for the EAAT binding site, satisfied by this structurally rigid pyrrolidine "conformer mimic" of glutamate. L-trans-Pyrrolidine-2,4-dicarboxylic acid is an inhibitor of EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5.

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