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L-Leucyl-L-Leucine methyl ester (hydrochloride)

L-Leucyl-L-Leucine methyl ester (hydrochloride) Structure
  • ₹0
  • Product name: L-Leucyl-L-Leucine methyl ester (hydrochloride)
  • CAS: 6491-83-4
  • MF: C13H27ClN2O3
  • MW: 294.81808
  • EINECS:
  • MDL Number:MFCD00155477
  • Synonyms:L-Leucyl-L-Leucine methyl ester (hydrochloride);methyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloride;Leu-Leu-ome hydrochloride;H-Leu-leu-OMe hydrochloride;L-Leucine, L-leucyl-, methyl ester, monohydrochloride;L-Leucyl-L-Leucine methyl ester;lymphocytes,leukocytes,monocytes,pathway,LLeucylLLeucine methyl ester hydrochloride,LLOMe,inhibit,polymorphonuclear,stress,Leu-Leu methyl ester,cytotoxic,Inhibitor,L Leucyl L Leucine methyl ester hydrochloride,Endogenous Metabolite,endolysosomal
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :177-181°C
storage temp. :Hygroscopic, Refrigerator, under inert atmosphere
solubility :DMSO (Slightly), Water (Slightly)
form :Solid
color :White to Off-White
Stability :Hygroscopic

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.

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Suppliers and manufacturers

A.J Chemicals
BOC Sciences
Nextpeptide Inc
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
LEAPCHEM CO., LTD.
Aladdin Scientific Shanghai Aladdin Biochemical Technology Co.,Ltd. Olix (Shanghai) Pharmaceutical Technology Co., Ltd Suzhou Daolan Biomedical Technology Co., Ltd.