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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >DNA damage >DNA / RNA Synthesis inhibitors >7-Nitroindole-2-carboxylic acid

7-Nitroindole-2-carboxylic acid

7-Nitroindole-2-carboxylic acid Structure
  • ₹9006.4 - ₹34531.75
  • Product name: 7-Nitroindole-2-carboxylic acid
  • CAS: 6960-45-8
  • MF: C9H6N2O4
  • MW: 206.15
  • EINECS:230-154-6
  • MDL Number:MFCD00044720
  • Synonyms:TIMTEC-BB SBB003487;7-nitro-1h-indole-2-carboxylicaci ;7-NITRO-1H-INDOLE-2-CARBOXYLIC ACID;7-NITROINDOLE-2-CARBOXYLIC ACID;7-Nitroindole-2-carboxylic acid, 90-95%;7-NO2-ICA;2-Carboxy-7-nitro-1H-indole;7-Nitro-1H-indole-2-carboxylic acid 95+%
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 25MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberC0496
  • Product descriptionCRT0044876 ≥98% (HPLC)
  • Packaging10MG
  • Price₹9006.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number262015
  • Product descriptionDNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem The DNA Base Excision Repair Pathway Inhibitor, also referenced under CAS 6960-45-8, controls the biological activity of APE1 (human apurinic/apyrimid
  • Packaging25MG
  • Price₹10670
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC0496
  • Product descriptionCRT0044876 ≥98% (HPLC)
  • Packaging50MG
  • Price₹34531.75
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C0496 CRT0044876 ≥98% (HPLC) 10MG ₹9006.4 2022-06-14 Buy
Sigma-Aldrich(India) 262015 DNA Base Excision Repair Pathway Inhibitor - CAS 6960-45-8 - Calbiochem The DNA Base Excision Repair Pathway Inhibitor, also referenced under CAS 6960-45-8, controls the biological activity of APE1 (human apurinic/apyrimid 25MG ₹10670 2022-06-14 Buy
Sigma-Aldrich(India) C0496 CRT0044876 ≥98% (HPLC) 50MG ₹34531.75 2022-06-14 Buy

Properties

Melting point :260-261 °C
Boiling point :344.99°C (rough estimate)
Density :1.4588 (rough estimate)
refractive index :1.5570 (estimate)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: >20mg/mL
form :Tan solid
pka :4.03±0.30(Predicted)
color :Light yellow to yellow
Water Solubility :Insoluble
CAS DataBase Reference :6960-45-8(CAS DataBase Reference)
EPA Substance Registry System :1H-Indole-2-carboxylic acid, 7-nitro- (6960-45-8)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Description

Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5’ to the abasic site to produce a single strand break. DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11 μM). Although not toxic to cells by itself at 200 μM, it enhances the cytotoxicity of certain DNA alkylating agents, including temozolomide, when added at this concentration. DNA base excision repair pathway inhibitor has little or no effect on radiation-induced cell survival.

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