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BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride

BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride Structure
  • ₹14260
  • Product name: BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
  • CAS: 935693-62-2
  • MF: C28H38N6O2
  • MW: 490.64
  • EINECS:
  • MDL Number:MFCD11045283
  • Synonyms:2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminetrihydrochloride;BIX 01294;BIX 01294 hydrate trihydrochloride;BIX 01294, 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride;4-QuinazolinaMine, 2-(hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6,7-diMethoxy-N-[1-(phenylMethyl)-4-piperidinyl]-;2-(Hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-6,7-diMethoxy-N-[1-(phenylMethyl)-4-piperidinyl]-4-quinazolinaMine hydrate trihydrochloride;BIX 01294 (free base);2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number382190
  • Product descriptionHistone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem The Histone Lysine Methyltransferase Inhibitor, also referenced under CAS 935693-62-2, controls the biological activity of Histone Lysine Methyltransf
  • Packaging5MG
  • Price₹14260
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 382190 Histone Lysine Methyltransferase Inhibitor - CAS 935693-62-2 - Calbiochem The Histone Lysine Methyltransferase Inhibitor, also referenced under CAS 935693-62-2, controls the biological activity of Histone Lysine Methyltransf 5MG ₹14260 2022-06-14 Buy

Properties

Boiling point :654.6±65.0 °C(Predicted)
Density :1.195±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml).
pka :9.34±0.70(Predicted)
form :Off-white solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey :BZOWJAYUMMHCDW-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Histone Lysine Methyltransferase Inhibitor (BIX-01294) is a G9a (histone lysine methyltransferase (HMTase)) inhibitor, specifically shown to inhibit the G9a-mediated generation of H3K9me2 (histone H3 lysine 9 dimethylation), not competitive with the S-adenosyl-methionine cofactor. Levels of H3K9me2 are restored with removal of BIX-01294. This molecule allows transient modulation of HMTase behavior, providing a tool for studying consequent effects on gene expression and chromatin organization. Histone Lysine Methyltransferase Inhibitor is an inhibitor of EHMT.

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N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
₹1.00 /1KG
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine CAS:935693-62-2
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