N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
![N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Structure](/CAS/GIF/17328-16-4.gif)
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- Product name: N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide)
- CAS: 17328-16-4
- MF: C16H14Cl2N2O4S
- MW: 401.26
- EINECS:
- MDL Number:MFCD00028183
- Synonyms:4',4'''-Sulfonylbis(α-chloroacetanilide);Bis[4-(chloroacetylamino)phenyl] sulfone;N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide);TC-E 5003;N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide);N'-(Sulfonyldi-4;1-phenylene)bis(2-chloroacetamide);TC-E 5003 (NSC-30176)
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Properties
Melting point :191-192 °C
Boiling point :704.2±60.0 °C(Predicted)
Density :1.504±0.06 g/cm3(Predicted)
storage temp. :-20°C (des.)
solubility :Soluble in DMSO (up to 50 mg/ml).
form :solid
pka :11.56±0.70(Predicted)
color :Brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Boiling point :704.2±60.0 °C(Predicted)
Density :1.504±0.06 g/cm3(Predicted)
storage temp. :-20°C (des.)
solubility :Soluble in DMSO (up to 50 mg/ml).
form :solid
pka :11.56±0.70(Predicted)
color :Brown
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
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Description
TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice.Related product price
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