AGM-1470
- ₹22390 - ₹91860.95
- Product name: AGM-1470
- CAS: 129298-91-5
- MF: C19H28ClNO6
- MW: 401.88
- EINECS:
- MDL Number:MFCD00870281
- Synonyms:NSC642492;O-(chloroacetylcarbamoyl)fumagillol;O-(CHLOROACETYLCARBAMOYL)FUMAGILLOLTNP-470 AGM-1470;[(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate;AGM-1470;Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester;Tnp-470;N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester
3 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product number654270
- Product descriptionTNP-470 - CAS 129298-91-5 - Calbiochem A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity, without affecting the inhibitory activity
- Packaging10MG
- Price₹22390
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT1455
- Product descriptionTNP-470 ≥98% (HPLC)
- Packaging5MG
- Price₹23511.9
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT1455
- Product descriptionTNP-470 ≥98% (HPLC)
- Packaging25MG
- Price₹91860.95
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 654270 | TNP-470 - CAS 129298-91-5 - Calbiochem A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity, without affecting the inhibitory activity | 10MG | ₹22390 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | T1455 | TNP-470 ≥98% (HPLC) | 5MG | ₹23511.9 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | T1455 | TNP-470 ≥98% (HPLC) | 25MG | ₹91860.95 | 2022-06-14 | Buy |
Properties
Melting point :90-93°C
alpha :D24 -46.6° (c = 0.44 in CHCl3)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >15mg/mL
pka :7.19±0.46(Predicted)
form :White to light yellow solid
color :White to Pale Yellow Waxy
Stability :Hygroscopic
alpha :D24 -46.6° (c = 0.44 in CHCl3)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >15mg/mL
pka :7.19±0.46(Predicted)
form :White to light yellow solid
color :White to Pale Yellow Waxy
Stability :Hygroscopic
Safety Information
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Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.More related product prices
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