AGM-1470
- CAS No.
- 129298-91-5
- Chemical Name:
- AGM-1470
- Synonyms
- Tnp-470;AGM-1470;NSC642492;TNP470,TNP 470;Fumagillin Impurity 1;O-Chloracetyl-carbamoyl fumagillol;O-(chloroacetylcarbamoyl)fumagillol;6-O-chloroacetylcarbamoylfumagillol;TNP-470 - CAS 129298-91-5 - Calbiochem;O-(chloroacetyl-carbaMoyl) fuMagillol,TNP-470
- CBNumber:
- CB11251062
- Molecular Formula:
- C19H28ClNO6
- Molecular Weight:
- 401.88
- MOL File:
- 129298-91-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:17
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 2 | |||||||||
| NFPA 704 |
|
AGM-1470 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T1455 | TNP-470 ≥98% (HPLC) | 129298-91-5 | 5MG | ₹23511.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T1455 | TNP-470 ≥98% (HPLC) | 129298-91-5 | 25MG | ₹91860.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 654270 | TNP-470 - CAS 129298-91-5 - Calbiochem A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity, without affecting the inhibitory activity | 129298-91-5 | 10MG | ₹22390 | 2022-06-14 | Buy |
AGM-1470 Chemical Properties,Uses,Production
Description
TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.
Uses
TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.
Definition
ChEBI: A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative.
General Description
TNP-470 is a synthetic analogue of fumagillin. It is a natural product of Aspergillus fumigatus. TNP-470 serves as an angiogenesis inhibitor.
Biological Activity
Analog of Fumagillin ((2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2 -methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5] oct-6-yl] 2,4,6,8-decatetraenedioic acid ester) that displays potent antiangiogenic activity in vitro and in vivo . Inhibits methionine aminopeptidase type II (MetAP2).
AGM-1470 Preparation Products And Raw materials
Raw materials
Preparation Products
AGM-1470 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9155 | 58 | Inquiry |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | China | 8255 | 55 | Inquiry |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | China | 4455 | 58 | Inquiry |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | China | 8141 | 58 | Inquiry |
| cuicheng bio | 13186333400 | China | 886 | 58 | Inquiry |
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