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AGM-1470

AGM-1470 Structure
  • ₹22390 - ₹91860.95
  • Product name: AGM-1470
  • CAS: 129298-91-5
  • MF: C19H28ClNO6
  • MW: 401.88
  • EINECS:
  • MDL Number:MFCD00870281
  • Synonyms:NSC642492;O-(chloroacetylcarbamoyl)fumagillol;O-(CHLOROACETYLCARBAMOYL)FUMAGILLOLTNP-470 AGM-1470;[(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate;AGM-1470;Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester;Tnp-470;N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number654270
  • Product descriptionTNP-470 - CAS 129298-91-5 - Calbiochem A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity, without affecting the inhibitory activity
  • Packaging10MG
  • Price₹22390
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT1455
  • Product descriptionTNP-470 ≥98% (HPLC)
  • Packaging25MG
  • Price₹91860.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT1455
  • Product descriptionTNP-470 ≥98% (HPLC)
  • Packaging5MG
  • Price₹23511.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 654270 TNP-470 - CAS 129298-91-5 - Calbiochem A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity, without affecting the inhibitory activity 10MG ₹22390 2022-06-14 Buy
Sigma-Aldrich(India) T1455 TNP-470 ≥98% (HPLC) 25MG ₹91860.95 2022-06-14 Buy
Sigma-Aldrich(India) T1455 TNP-470 ≥98% (HPLC) 5MG ₹23511.9 2022-06-14 Buy

Properties

Melting point :90-93°C
alpha :D24 -46.6° (c = 0.44 in CHCl3)
Density :1.26±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >15mg/mL
pka :7.19±0.46(Predicted)
form :White to light yellow solid
color :White to Pale Yellow Waxy
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

TNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.

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