AS601245
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- ₹20250
- Product name: AS601245
- CAS: 345987-15-7
- MF: C20H16N6S
- MW: 372.45
- EINECS:
- MDL Number:MFCD07772196
- Synonyms:AS601245;AS601245.TFA;JNK Inhibitor V;alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile;2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile;2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-;CS-1619;2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile
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Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product number420129
- Product descriptionJNK Inhibitor V - CAS 345987-15-7 - Calbiochem The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used f
- Packaging5MG
- Price₹20250
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 420129 | JNK Inhibitor V - CAS 345987-15-7 - Calbiochem The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used f | 5MG | ₹20250 | 2022-06-14 | Buy |
Properties
Boiling point :635.6±65.0 °C(Predicted)
Density :1.366±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥14.25 mg/mL in DMSO
pka :5.32±0.10(Predicted)
form :White to yellow solid.
color :Light yellow to yellow
Density :1.366±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥14.25 mg/mL in DMSO
pka :5.32±0.10(Predicted)
form :White to yellow solid.
color :Light yellow to yellow
Safety Information
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Description
c-Jun N-terminal kinases (JNKs) phosphorylate c-Jun and regulate transcription in response to an array of inflammatory signals. JNK inhibitor V is an ATP-competitive inhibitor of JNK1, JNK2, and JNK3 (IC50s = 150, 220, and 70 nM, respectively). While initial studies demonstrated 10- to 100-fold selectivity for JNK isoforms over a panel of 25 other kinases, strong interactions of JNK inhibitor V with GSK3B, Pim-1, Pim-3, and other kinases, evaluated as a shift in thermal melting point, suggest additional targets exist. In vivo efficacy of JNK inhibitor V against JNK isoforms has been demonstrated in gerbils, mice, and rats via oral, intravenous, or intraperitoneal administration. This compound is commonly used to investigate the role of JNK signaling in cells and animals.Related product price
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Suppliers and manufacturers
career henan chemical co
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2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile CAS:345987-15-7
2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile CAS:345987-15-7