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AZD5153

AZD5153 Structure
  • ₹0
  • Product name: AZD5153
  • CAS: 1869912-39-9
  • MF: C25H33N7O3
  • MW: 479.57
  • EINECS:
  • MDL Number:MFCD30530420
  • Synonyms:CPD1544;AZD5153; AZD-5153; AZD 5153;CS-2562;2-Piperazinone, 4-[2-[4-[1-(3-methoxy-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy]ethyl]-1,3-dimethyl-, (3R)-
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Density :1.34±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :crystalline solid
pka :7.57±0.40(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.

Description

AZD 5153 an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two bromodomains in BRD4, which has been shown to increase antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma.

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Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
Career Henan Chemica Co
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Aladdin Scientific
Suzhou ARTK Medchem Co., Ltd.
Amadis Chemical Company Limited Shanghai Hao Zhun Biological Technology Co., Ltd. Angel Pharmatech, Ltd. ApexBio Technology