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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Antiarrhythmics Drugs >Amiodarone hydrochloride

Amiodarone hydrochloride

Amiodarone hydrochloride Structure
  • ₹2300 - ₹38731.85
  • Product name: Amiodarone hydrochloride
  • CAS: 19774-82-4
  • MF: C25H29I2NO3.ClH
  • MW: 681.77
  • EINECS:243-293-2
  • MDL Number:MFCD00069204
  • Synonyms:2-BUTYL-3-BENZOFURANYL 4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL KETONE HYDROCHLORIDE;(2-BUTYL-3-BENZOFURANYL)-[4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODO-PHENYL]-METHANONE HYDROCHLORIDE;AMIODARONE-D4 HCL;AMIODARONE HYDROCHLORIDE;AMIODARONUM HYDROCHLORIDE;2-butyl-3-benzofuryl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride ;AMIODARONEHCL(2-BUTYL-3-BENZOFURANYL-4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYLKETONE);ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl, hydamiodaronum hydrochloride
7 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1ML
  • 1G
  • 5G
  • 10G
  • ManufacturerTCI Chemicals (India)
  • Product numberA2530
  • Product descriptionAmiodarone Hydrochloride
  • Packaging1G
  • Price₹2300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA2530
  • Product descriptionAmiodarone Hydrochloride
  • Packaging5G
  • Price₹6100
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA8423
  • Product descriptionAmiodarone hydrochloride ≥98%
  • Packaging1G
  • Price₹7090.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1164
  • Product descriptionAmiodarone hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹9093
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA-060
  • Product descriptionAmiodarone hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹12661.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA8423
  • Product descriptionAmiodarone hydrochloride ≥98%
  • Packaging5G
  • Price₹23122.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA8423
  • Product descriptionAmiodarone hydrochloride ≥98%
  • Packaging10G
  • Price₹38731.85
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) A2530 Amiodarone Hydrochloride 1G ₹2300 2022-05-26 Buy
TCI Chemicals (India) A2530 Amiodarone Hydrochloride 5G ₹6100 2022-05-26 Buy
Sigma-Aldrich(India) A8423 Amiodarone hydrochloride ≥98% 1G ₹7090.38 2022-06-14 Buy
Sigma-Aldrich(India) PHR1164 Amiodarone hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹9093 2022-06-14 Buy
Sigma-Aldrich(India) A-060 Amiodarone hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹12661.6 2022-06-14 Buy
Sigma-Aldrich(India) A8423 Amiodarone hydrochloride ≥98% 5G ₹23122.2 2022-06-14 Buy
Sigma-Aldrich(India) A8423 Amiodarone hydrochloride ≥98% 10G ₹38731.85 2022-06-14 Buy

Properties

Melting point :154-158°C
Flash point :9℃
storage temp. :2-8°C
solubility :Soluble in chloroform, methanol.
pka :pKa (25°C) 6.56 ±0.06
form :Solid
color :White
λmax :242nm(MeOH)(lit.)
Merck :14,482
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
CAS DataBase Reference :19774-82-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6, 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

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