Aprepitant
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- ₹8000 - ₹20112.85
- Product name: Aprepitant
- CAS: 170729-80-3
- MF: C23H21F7N4O3
- MW: 534.43
- EINECS:677-636-6
- MDL Number:MFCD08277635
- Synonyms:MK-0869;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend;Aprepitant(MK-0869);ONO 7436;5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholino)Methyl)-1H-1,2,4-triazol-3(2H)-one;Aprepirant;aprepitant
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- 100MG
- 500MG
- ManufacturerTCI Chemicals (India)
- Product numberA3135
- Product descriptionAprepitant
- Packaging100MG
- Price₹8000
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberA3135
- Product descriptionAprepitant
- Packaging500MG
- Price₹15000
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML2215
- Product descriptionAprepitant ≥98% (HPLC)
- Packaging5MG
- Price₹9331.15
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML2215
- Product descriptionAprepitant ≥98% (HPLC)
- Packaging25MG
- Price₹20112.85
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | A3135 | Aprepitant | 100MG | ₹8000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A3135 | Aprepitant | 500MG | ₹15000 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | SML2215 | Aprepitant ≥98% (HPLC) | 5MG | ₹9331.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML2215 | Aprepitant ≥98% (HPLC) | 25MG | ₹20112.85 | 2022-06-14 | Buy |
Properties
Melting point :244-246°C
alpha :D25 +69° (c = 1.00 in methanol)
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :8.06±0.20(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +61 to +71°, c = 1.0 in methanol
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :170729-80-3(CAS DataBase Reference)
alpha :D25 +69° (c = 1.00 in methanol)
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :8.06±0.20(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +61 to +71°, c = 1.0 in methanol
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :170729-80-3(CAS DataBase Reference)
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Substance P, a neurokinin peptide found in the brain and gastrointestinal tract, is thought to modulate stress responses, including the emetic reflex. Its actions are mediated through the neurokinin-1 (NK1) receptor, one of three GPCRs that couple neurokinin binding to the inositol phosphate signal transduction pathway. Aprepitant is an anti-emetic compound that selectively antagonizes the human NK1 receptor (Kis = 3 and 454.1 nM for hNK1 and hNK3, respectively; IC50 = 0.09 nM for hNK1). In in vivo assays to measure peripheral (guinea pig SYVAL assay) and central (gerbil foot-tapping stress response assay) inhibition of NK1 receptors, aprepitant demonstrates ED50 values of 0.008 and 0.36 mg/kg, respectively. Through antagonism of NK1 receptor activity, aprepitant has found clinical use to prevent chemotherapy-induced nausea and vomiting.More related product prices
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