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ChemicalBook > Product Catalogue >Biochemical Engineering >Enzymes And Coenzymes drugs >Aprotinin

Aprotinin

Aprotinin Structure
  • ₹1870 - ₹442768.48
  • Product name: Aprotinin
  • CAS: 9087-70-1
  • MF: C284H432N84O78R2S7
  • MW: 6495.43988
  • EINECS:232-994-9
  • MDL Number:MFCD00130541
  • Synonyms:TRYPSIN INHIBITOR, PANCREAS TYPE;TRYPSIN INHIBITOR (BASIC);TRYPSIN INHIBITOR, BOVINE LUNG;TRASYLOL;antikrein ;antilysin ;antilysine ;aprotininfrombovinelung
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  • Sigma-Aldrich(India)
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  • 616370-20MG
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  • 5X10ML
  • 1VIAL
  • 616370-1GM
  • 616370-10MG
  • 616370-100MG
  • 500ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberA1153
  • Product descriptionAprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid
  • Packaging1MG
  • Price₹4773.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number10820
  • Product descriptionAprotinin from bovine lung lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500?U/mg
  • Packaging5MG
  • Price₹6819.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number616371
  • Product descriptionAprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem recombinant, expressed in Nicotiana, heat and acid-stable competitive, reversible inhibitor of serine proteases
  • Packaging1MG
  • Price₹7070
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number616370-M
  • Product descriptionAprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem Aprotinin, Bovine Lung, Crystalline, CAS 9087-70-1, is a competitive, reversible, heat- and acid-stable inhibitor of proteolytic and esterolytic activ
  • Packaging616370-10MG
  • Price₹9400
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number616371
  • Product descriptionAprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem recombinant, expressed in Nicotiana, heat and acid-stable competitive, reversible inhibitor of serine proteases
  • Packaging5MG
  • Price₹9490
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4529
  • Product descriptionAprotinin from bovine lung lyophilized powder, 3-7?TIU/mg solid
  • Packaging1MG
  • Price₹9969.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number616370-M
  • Product descriptionAprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem Aprotinin, Bovine Lung, Crystalline, CAS 9087-70-1, is a competitive, reversible, heat- and acid-stable inhibitor of proteolytic and esterolytic activ
  • Packaging616370-1GM
  • Price₹442768.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA3428
  • Product descriptionAprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid, BioReagent, suitable for cell culture
  • Packaging100MG
  • Price₹130235.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6106
  • Product descriptionAprotinin from bovine lung BioUltra, 3-8?TIU/mg solid, ≥98% (SDS-PAGE)
  • Packaging100MG
  • Price₹151636.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA1153
  • Product descriptionAprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid
  • Packaging250MG
  • Price₹194525.25
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSRE0078
  • Product descriptionAprotinin from bovine lung lyophilized powder, ≥3?TIU/mg solid, Suitable for manufacturing of diagnostic kits and reagents
  • Packaging250MG
  • Price₹232423.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA3428
  • Product descriptionAprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid, BioReagent, suitable for cell culture
  • Packaging250MG
  • Price₹240672.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA4529
  • Product descriptionAprotinin from bovine lung lyophilized powder, 3-7?TIU/mg solid
  • Packaging100MG
  • Price₹240672.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSRE0078
  • Product descriptionAprotinin from bovine lung lyophilized powder, ≥3?TIU/mg solid, Suitable for manufacturing of diagnostic kits and reagents
  • Packaging100MG
  • Price₹88039.73
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA1153
  • Product descriptionAprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid
  • Packaging100MG
  • Price₹98918.85
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberA6279
  • Product descriptionAprotinin from bovine lung saline solution, 3-7?TIU/mg protein
  • Packaging50ML
  • Price₹99893.1
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) A1153 Aprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid 1MG ₹4773.83 2022-06-14 Buy
Sigma-Aldrich(India) 10820 Aprotinin from bovine lung lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500?U/mg 5MG ₹6819.75 2022-06-14 Buy
Sigma-Aldrich(India) 616371 Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem recombinant, expressed in Nicotiana, heat and acid-stable competitive, reversible inhibitor of serine proteases 1MG ₹7070 2022-06-14 Buy
Sigma-Aldrich(India) 616370-M Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem Aprotinin, Bovine Lung, Crystalline, CAS 9087-70-1, is a competitive, reversible, heat- and acid-stable inhibitor of proteolytic and esterolytic activ 616370-10MG ₹9400 2022-06-14 Buy
Sigma-Aldrich(India) 616371 Aprotinin, Bovine, Recombinant, Nicotiana sp., Animal-Free - CAS 9087-70-1 - Calbiochem recombinant, expressed in Nicotiana, heat and acid-stable competitive, reversible inhibitor of serine proteases 5MG ₹9490 2022-06-14 Buy
Sigma-Aldrich(India) A4529 Aprotinin from bovine lung lyophilized powder, 3-7?TIU/mg solid 1MG ₹9969.83 2022-06-14 Buy
Sigma-Aldrich(India) 616370-M Aprotinin, Bovine Lung, Crystalline - CAS 9087-70-1 - Calbiochem Aprotinin, Bovine Lung, Crystalline, CAS 9087-70-1, is a competitive, reversible, heat- and acid-stable inhibitor of proteolytic and esterolytic activ 616370-1GM ₹442768.48 2022-06-14 Buy
Sigma-Aldrich(India) A3428 Aprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid, BioReagent, suitable for cell culture 100MG ₹130235.58 2022-06-14 Buy
Sigma-Aldrich(India) A6106 Aprotinin from bovine lung BioUltra, 3-8?TIU/mg solid, ≥98% (SDS-PAGE) 100MG ₹151636.6 2022-06-14 Buy
Sigma-Aldrich(India) A1153 Aprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid 250MG ₹194525.25 2022-06-14 Buy
Sigma-Aldrich(India) SRE0078 Aprotinin from bovine lung lyophilized powder, ≥3?TIU/mg solid, Suitable for manufacturing of diagnostic kits and reagents 250MG ₹232423.58 2022-06-14 Buy
Sigma-Aldrich(India) A3428 Aprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid, BioReagent, suitable for cell culture 250MG ₹240672.23 2022-06-14 Buy
Sigma-Aldrich(India) A4529 Aprotinin from bovine lung lyophilized powder, 3-7?TIU/mg solid 100MG ₹240672.23 2022-06-14 Buy
Sigma-Aldrich(India) SRE0078 Aprotinin from bovine lung lyophilized powder, ≥3?TIU/mg solid, Suitable for manufacturing of diagnostic kits and reagents 100MG ₹88039.73 2022-06-14 Buy
Sigma-Aldrich(India) A1153 Aprotinin from bovine lung lyophilized powder, 3-8?TIU/mg solid 100MG ₹98918.85 2022-06-14 Buy
Sigma-Aldrich(India) A6279 Aprotinin from bovine lung saline solution, 3-7?TIU/mg protein 50ML ₹99893.1 2022-06-14 Buy

Properties

Melting point :>234oC (dec.)
storage temp. :2-8°C
solubility :glycerol: soluble3mg/mL, clear, colorless (equilibration buffer containing 5% glycerol)
form :lyophilized powder
color :white
Water Solubility :Freely soluble in water and in aqueous buffers of low ionic strength.
Merck :13,761
Sequence :H-Pro-Asp-Phe-Cys-Leu-Glu-Pro-Pro-Tyr-Thr-Gly-Pro-Cys-Lys-Ala-Arg-Ile-Ile-Arg-Tyr-Phe-Tyr-Asn-Ala-Lys-Ala-Gly-Leu-Cys-Gln-Thr-Phe-Val-Tyr-Gly-Gly-Cys-Arg-Ala-Lys-Arg-Asn-Asn-Phe-Lys-Ser-Ala-Glu-Asp-Cys-Met-Arg-Thr-Cys-Gly-Gly-Ala-OH
Stability :Stable. Incompatible with strong oxidizing agents.
InChIKey :RWLBZZCCAZDWSE-BNRYNCRGNA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Aprotinin is a reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM). It is a much weaker inhibitor of thrombin (Ki = 0.1-0.8 mM) and trypsinogen (Ki = 2 μM). Aprotinin also competitively inhibits nNOS and iNOS with Ki values of 50 and 78 μM, respectively. Aprotinin is widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.

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