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ChemicalBook > Product Catalogue >Biochemical Engineering >Chinese Herbs >(-)-Arctigenin

(-)-Arctigenin

(-)-Arctigenin Structure
  • ₹6500 - ₹25687.73
  • Product name: (-)-Arctigenin
  • CAS: 7770-78-7
  • MF: C21H24O6
  • MW: 372.41
  • EINECS:
  • MDL Number:MFCD00870597
  • Synonyms:(3R,4R)-4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-2(3H)-FURANONE;2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-,(3R,4R);2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL];ARCTIGENIN:2(3H)-FURANONE,4-[(3,4-DIMETHOXYPHENYL)METHYL]DIHYDRO-3-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-,(3R,4R);2(3H)-Furanone,4-[(3,4-dimethoxyphenyl) methyl];dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-,(3R,4R)-;(-)-ARCTIGENIN;ARCTIGENIN
3 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1MG
  • 10MG
  • 50MG
  • ManufacturerTCI Chemicals (India)
  • Product numberA3117
  • Product description(-)-Arctigenin min. 95.0 %
  • Packaging10MG
  • Price₹6500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberA3117
  • Product description(-)-Arctigenin min. 95.0 %
  • Packaging50MG
  • Price₹14800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSMB00075
  • Product description(−)-Arctigenin ≥95% (LC/MS-ELSD)
  • Packaging1MG
  • Price₹25687.73
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) A3117 (-)-Arctigenin min. 95.0 % 10MG ₹6500 2022-05-26 Buy
TCI Chemicals (India) A3117 (-)-Arctigenin min. 95.0 % 50MG ₹14800 2022-05-26 Buy
Sigma-Aldrich(India) SMB00075 (−)-Arctigenin ≥95% (LC/MS-ELSD) 1MG ₹25687.73 2022-06-14 Buy

Properties

Melting point :98.0 to 102.0 °C
Boiling point :567.0±45.0 °C(Predicted)
Density :1.227±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: 34 mg/mL with heating and sonicating, soluble
form :solid
pka :10.03±0.20(Predicted)
color :White to Light yellow
λmax :280nm(EtOH)(lit.)
InChIKey :NQWVSMVXKMHKTF-JKSUJKDBSA-N
LogP :2.470 (est)
CAS DataBase Reference :7770-78-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt induced by glucose starvation in pancreatic cancer PANC-1 cells, which is a key process in the tolerance exhibited by cancer cells to glucose starvation. It has potent in vitro antiviral activities against in?uenza A virus and shows neuroprotective effects against an experimental mouse model of Japanese encephalitis. Arctigenin also demonstrates a therapeutic effect in ischemic stroke treatment of middle cerebral artery occluded rats by suppressing microglia activation and decreasing IL-1β and TNF-α expression.

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