Atractylenolide-1
- ₹20145.33 - ₹67764.5
- Product name: Atractylenolide-1
- CAS: 73069-13-3
- MF: C15H18O2
- MW: 230.3
- EINECS:
- MDL Number:MFCD09037395
- Synonyms:ATRACTYLENOLIDE-1;3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one;Eudesma-4(15),7(11),8-trien-12-olide;8,9-Dehydroasterolide;(4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one;Atractylenolide Ⅰ;Atractylenolide I, >99%;Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- ManufacturerSigma-Aldrich(India)
- Product numberA2737
- Product descriptionAtractylenolide I ≥98% (HPLC)
- Packaging10MG
- Price₹20145.33
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberA2737
- Product descriptionAtractylenolide I ≥98% (HPLC)
- Packaging50MG
- Price₹67764.5
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | A2737 | Atractylenolide I ≥98% (HPLC) | 10MG | ₹20145.33 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | A2737 | Atractylenolide I ≥98% (HPLC) | 50MG | ₹67764.5 | 2022-06-14 | Buy |
Properties
Melting point :121-123 °C(Solv: ligroine (8032-32-4))
Boiling point :405.0±44.0 °C(Predicted)
Density :1.12
Flash point :170℃
storage temp. :2-8°C
solubility :methanol: soluble1mg/mL, clear, colorless
form :powder
color :White
InChIKey :ZTVSGQPHMUYCRS-SWLSCSKDSA-N
Boiling point :405.0±44.0 °C(Predicted)
Density :1.12
Flash point :170℃
storage temp. :2-8°C
solubility :methanol: soluble1mg/mL, clear, colorless
form :powder
color :White
InChIKey :ZTVSGQPHMUYCRS-SWLSCSKDSA-N
Safety Information
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Description
Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.More related product prices
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