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ChemicalBook > Product Catalogue >API >Anesthetic Agents >Skeletal muscle relaxants >Baclofen

Baclofen

Baclofen Structure
  • ₹3300 - ₹55023.48
  • Product name: Baclofen
  • CAS: 1134-47-0
  • MF: C10H12ClNO2
  • MW: 213.66
  • EINECS:214-486-9
  • MDL Number:MFCD00055143
  • Synonyms:4-Amino-3-(p-chlorophenyl)butyric acid;Benzenepropanoic acid, β-(aminomethyl)-4-chloro-;CIBA Ba 34647;DL-4-Amino-3-p-chlorophenylbutanoic acid;DL-Baclofen;Hydrocinnamic acid, β-(aminomethyl)-p-chloro- (7CI, 8CI);β-(4-Chlorophenyl)-γ-aminobutyric acid;β-p-Chlorophenyl-GABA
7 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 500MG
  • 1G
  • 5G
  • 10G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberB3343
  • Product descriptionBaclofen
  • Packaging1G
  • Price₹3300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB3343
  • Product descriptionBaclofen
  • Packaging5G
  • Price₹12600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB3343
  • Product descriptionBaclofen
  • Packaging25G
  • Price₹13800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB5399
  • Product description(±)-Baclofen ≥98% (TLC), solid
  • Packaging500MG
  • Price₹5639.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1682
  • Product descriptionBaclofen Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹13520.43
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB5399
  • Product description(±)-Baclofen ≥98% (TLC), solid
  • Packaging5G
  • Price₹30429.08
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB5399
  • Product description(±)-Baclofen ≥98% (TLC), solid
  • Packaging10G
  • Price₹55023.48
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B3343 Baclofen 1G ₹3300 2022-05-26 Buy
TCI Chemicals (India) B3343 Baclofen 5G ₹12600 2022-05-26 Buy
TCI Chemicals (India) B3343 Baclofen 25G ₹13800 2022-05-26 Buy
Sigma-Aldrich(India) B5399 (±)-Baclofen ≥98% (TLC), solid 500MG ₹5639.83 2022-06-14 Buy
Sigma-Aldrich(India) PHR1682 Baclofen Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹13520.43 2022-06-14 Buy
Sigma-Aldrich(India) B5399 (±)-Baclofen ≥98% (TLC), solid 5G ₹30429.08 2022-06-14 Buy
Sigma-Aldrich(India) B5399 (±)-Baclofen ≥98% (TLC), solid 10G ₹55023.48 2022-06-14 Buy

Properties

Melting point :208-210°C
Boiling point :364.3±32.0 °C(Predicted)
Density :1.2069 (rough estimate)
refractive index :1.5500 (estimate)
storage temp. :2-8°C
solubility :1 M HCl: 50 mg/mL
form :solid
pka :pKa 3.87±0.1(H2O) (Uncertain)
color :white to very faintly yellow
Water Solubility :Soluble in dilute NaOH or dilute HCl. Soluble in water at approximately 4mg/ml at pH 7.6
Merck :14,937
Stability :Hygroscopic
InChI :InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChIKey :KPYSYYIEGFHWSV-UHFFFAOYSA-N
SMILES :C1(C=CC(Cl)=CC=1)C(CN)CC(=O)O
CAS DataBase Reference :1134-47-0(CAS DataBase Reference)
NIST Chemistry Reference :Baclofen(1134-47-0)
EPA Substance Registry System :.beta.-(Aminomethyl)-4-chlorobenzenepropanoic acid (1134-47-0)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:

Description

γ-Aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through heteromeric ligand-gated ion channels, GABAA and GABAC, and a G protein-coupled receptor, GABAB. (±)-Baclofen is a selective agonist of GABAB (IC50 = 200 nM). By activating GABAB, (±)-baclofen causes skeletal muscle relaxation and blocks spasticity. It also modifies animal responses to alcohol and cocaine.

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