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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Metabolism >Retinoid Receptor Inhibitors >Bexarotene

Bexarotene

Bexarotene Structure
  • ₹9482.7 - ₹38417.93
  • Product name: Bexarotene
  • CAS: 153559-49-0
  • MF: C24H28O2
  • MW: 348.48
  • EINECS:
  • MDL Number:MFCD00932428
  • Synonyms:LG 69;RO 26-4455;SR 11247;Targret;Bexarotene(4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)ethenyl]benzoic acid;Bexarotene, Free;Bexzarotene;Bexarotene - CAS 153559-49-0 - Calbiochem
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB4798
  • Product descriptionBexarotene
  • Packaging100MG
  • Price₹14500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0282
  • Product descriptionBexarotene ≥98% (HPLC)
  • Packaging10MG
  • Price₹9482.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number200499
  • Product descriptionBexarotene - CAS 153559-49-0 - Calbiochem A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-depen
  • Packaging50MG
  • Price₹13870
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0282
  • Product descriptionBexarotene ≥98% (HPLC)
  • Packaging50MG
  • Price₹38417.93
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B4798 Bexarotene 100MG ₹14500 2022-05-26 Buy
Sigma-Aldrich(India) SML0282 Bexarotene ≥98% (HPLC) 10MG ₹9482.7 2022-06-14 Buy
Sigma-Aldrich(India) 200499 Bexarotene - CAS 153559-49-0 - Calbiochem A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-depen 50MG ₹13870 2022-06-14 Buy
Sigma-Aldrich(India) SML0282 Bexarotene ≥98% (HPLC) 50MG ₹38417.93 2022-06-14 Buy

Properties

Melting point :230-231°C
Boiling point :489.7±44.0 °C(Predicted)
Density :1.042
RTECS :DH6834830
storage temp. :-20°C
solubility :Soluble in DMSO and ethanol
form :White powder
pka :4.08±0.10(Predicted)
color :white to beige
λmax :264nm(MeOH)(lit.)
Merck :14,1194
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
InChIKey :NAVMQTYZDKMPEU-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Bexarotene is a high-affinity ligand for retinoid X receptors (RXRs) (EC50 = 28, 25, and 20 nM for RXRα, β, and γ, respectively). It inhibits cell cycle progression, induces apoptosis, prevents or overcomes multidrug resistance through multidrug resistance protein 1 (MDR1), and blocks angiogenesis and metastasis, making it a promising chemopreventive agent against cancer. Bexarotene also, through RXR activation, stimulates clearance of soluble β-amyloid, reduces plaque area, and reverses deficits related to Alzheimer’s disease in mice.

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