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Bisindolylmaleimide V

Bisindolylmaleimide V Structure
  • ₹7070 - ₹22650
  • Product name: Bisindolylmaleimide V
  • CAS: 113963-68-1
  • MF: C21H15N3O2
  • MW: 341.36
  • EINECS:604-604-1
  • MDL Number:MFCD00236433
  • Synonyms:1-Methyl-3,4-bis(indol-3-yl)maleimide, Ro 31-6045;1-Methyl 3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione;1-Methyl-3-(1H-indole-3-yl)-4-(1H-indole-3-yl)-1H-pyrrole-2,5-dione;1-Methyl-3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione;3,4-Bis(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione;3,4-Bis(1H-indole-3-yl)-1-methyl-3-pyrroline-2,5-dione;BISINDOLYLMALEIMIDE V;3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 400μG
  • 1MG
  • ManufacturerSigma-Aldrich(India)
  • Product number203303
  • Product descriptionBisindolylmaleimide V - CAS 113963-68-1 - Calbiochem A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM).
  • Packaging1MG
  • Price₹22650
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number203303
  • Product descriptionBisindolylmaleimide V - CAS 113963-68-1 - Calbiochem A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM).
  • Packaging400μG
  • Price₹7070
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 203303 Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM). 1MG ₹22650 2022-06-14 Buy
Sigma-Aldrich(India) 203303 Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM). 400μG ₹7070 2022-06-14 Buy

Properties

Melting point :>260 °C
Boiling point :655.7±55.0 °C(Predicted)
Density :1.450±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble
form :solid
pka :15.89±0.30(Predicted)
color :Orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference :113963-68-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Bisindolylmaleimide V (BIM V) is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 μM. While effectively inactive as a PKC inhibitor, BIM V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 μM.

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