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ChemicalBook > Product Catalogue >Natural Products >Alkaloids >CASTANOSPERMINE

CASTANOSPERMINE

CASTANOSPERMINE Structure
  • ₹5880 - ₹10164.68
  • Product name: CASTANOSPERMINE
  • CAS: 79831-76-8
  • MF: C8H15NO4
  • MW: 189.21
  • EINECS:
  • MDL Number:MFCD00017555
  • Synonyms:1,6,7,8-indolizinetetrol,octahydro-,(1s-(1-alpha,6-beta,7-alpha,8-beta,8a-bet ;7,8-indolizinetetrol,octahydro-,(1s,6s,7r,8r,8ar)-6 ;octahydro-1,6,7,8-indolizinetetrol(1s-(1-alpha,6-beta,7-alpha,8-beta,8a-beta ;CASTANOSPERMINE;CASTANOSPERMINE, CASTANOSPERMUM AUSTRALE;[1S-(1A,6B,7A,8B,8A-BETA)]-OCTAHYDRO-1,6,7,8-INDOLIZINETETROL;(1S,6S,7R,8AR)-TETRAHYDROXYOCTAHYDROINDOLIZINE;(1S,6S,7R,8R,8AR)-1,6,7,8-TETRAHYDROXYINDOLIZIDINE
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 100MG
  • ManufacturerSigma-Aldrich(India)
  • Product number218775
  • Product descriptionCastanospermine, Castanospermum australe - CAS 79831-76-8 - Calbiochem Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins.
  • Packaging1MG
  • Price₹5880
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number532673
  • Product description(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine 98%
  • Packaging100MG
  • Price₹10164.68
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 218775 Castanospermine, Castanospermum australe - CAS 79831-76-8 - Calbiochem Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. 1MG ₹5880 2022-06-14 Buy
Sigma-Aldrich(India) 532673 (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine 98% 100MG ₹10164.68 2022-06-14 Buy

Properties

Melting point :213-217 °C (lit.)
alpha :D25 +79.7° (c = 0.93 in water)
Boiling point :421.9±45.0 °C(Predicted)
Density :1.53±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :1 M HCl: 20 mg/mL, clear, very faintly yellow
form :White solid
pka :6.09(at 25℃)
color :White or off-white
optical activity :[α]20/D +80°, c = 0.9 in H2O
Water Solubility :Soluble in water
Merck :13,1906
BRN :3588654
Stability :Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference :79831-76-8(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P321 Specific treatment (see … on this label).

Description

Glucosidases catalyze the cleavage of individual glucosyl residues from various glycoconjugates, including complex carbohydrates and glycoproteins. Castanospermine is an inhibitor of both α- and β-glucosidases, inhibiting lysosomal and neutral α-glucosidases with Ki values of 0.1 and 10 μM, respectively, and lysosomal and cytosolic β-glucosidases with Ki values of 7 and 40 μM, respectively. It is effective both in vitro and in vivo. Through its effects on glucosidases, castanospermine blocks N-linked glycosylation during post-translational modification of proteins, affecting protein trafficking and cell functions that are dependent on glycosylation, including angiogenesis. Castanospermine also interferes with viral replication and infection that is dependent on glucosidase activity.

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