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ChemicalBook > Product Catalogue >Biochemical Engineering >Plant extracts >CONESSINE

CONESSINE

CONESSINE Structure
  • ₹5001.15 - ₹17698.88
  • Product name: CONESSINE
  • CAS: 546-06-5
  • MF: C24H40N2
  • MW: 356.59
  • EINECS:208-897-2
  • MDL Number:MFCD00016752
  • Synonyms:3-beta-(dimethylamino)-con-5-enin ;3-beta-(dimethylamino)con-5-enine ;n,18-dihydrotrimethyl-conkurchin ;n-dimethyl-(3-beta)-con-5-enin-3-amin ;WRIGHTINE;NERVINE;NERIINE;ROGUESSINE
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0095
  • Product descriptionConessine ≥97% (HPLC)
  • Packaging10MG
  • Price₹5001.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0095
  • Product descriptionConessine ≥97% (HPLC)
  • Packaging50MG
  • Price₹17698.88
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0095 Conessine ≥97% (HPLC) 10MG ₹5001.15 2022-06-14 Buy
Sigma-Aldrich(India) SML0095 Conessine ≥97% (HPLC) 50MG ₹17698.88 2022-06-14 Buy

Properties

Melting point :126-127°C
alpha :D20 +25.3° (c = 0.7 in abs alc)
Boiling point :479.38°C (rough estimate)
Density :0.9492 (rough estimate)
refractive index :1.5640 (estimate)
storage temp. :Store at RT
solubility :ethanol: ≥2mg/mL
form :powder
pka :10.20±0.70(Predicted)
color :white to tan
LogP :6.060 (est)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Conessine is a naturally occurring steroid alkaloid found in a number of plant species from the Apocynaceae family, which have been used in traditional herbal medicine as a treatment for amoebic dysentery. In a radioligand-based high-throughput screen, conessine demonstrated high affinity for both rat and human histamine H3 receptors (Kis = 5.2 and 24.5 nM, respectively) and high selectivity against histamine receptors H1, H2, and H4. Though conessine potently blocks H3 agonist-stimulated GTPγS binding in cell- and tissue-based functional assays and efficiently crosses the blood-brain barrier, it has a poor rate of CNS clearance.

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