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CROMAKALIM

CROMAKALIM Structure
  • ₹18824.68 - ₹75179.63
  • Product name: CROMAKALIM
  • CAS: 94470-67-4
  • MF: C16H18N2O3
  • MW: 286.33
  • EINECS:
  • MDL Number:MFCD00133201
  • Synonyms:Cromakalim=([+/-]-trans-6-Cyano-3,4-dihydro-2,2-;(+/-)-CROMAKALIM;CROMAKALIM;TRANS-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE;(+/-)-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-(2-OXOPYRROLIDIN-1-YL)-2H-1-BENZOPYRAN-3-OL;[+/-]-TRANS-6-CYANO-3,4-DIHYDRO-2,2-DIMETHYL-4-[2-OXOPYRROLIDIN-1-YL]-2H-1-BENZOPYRAN-3-OL;BRL-34915;rac-(3α*,4β*)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidine-1-yl)-2H-1-benzopyran-6-carbonitrile
2 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1055
  • Product descriptionCromakalim
  • Packaging10MG
  • Price₹18824.68
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1055
  • Product descriptionCromakalim
  • Packaging50MG
  • Price₹75179.63
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C1055 Cromakalim 10MG ₹18824.68 2022-06-14 Buy
Sigma-Aldrich(India) C1055 Cromakalim 50MG ₹75179.63 2022-06-14 Buy

Properties

Melting point :242-244°C
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
form :solid
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

(±)-Cromakalim is a prototypical activator of the ATP-sensitive potassium channel, SUR2-Kir6, that displays anti-ischemic (EC25 = 8.9 μM) and cardioprotective (IC50 = 0.03 μM) effects in rat hearts. (±)-Cromakalim has also been shown to relax bladder smooth muscle in vitro. It has been used to investigate potassium channel biology and as a scaffold to develop increasingly selective K+ channel openers with clinical relevance.

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