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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Antihypertensive drugs >Captopril

Captopril

Captopril Structure
  • ₹7070 - ₹74097.13
  • Product name: Captopril
  • CAS: 62571-86-2
  • MF: C9H15NO3S
  • MW: 217.29
  • EINECS:263-607-1
  • MDL Number:MFCD00168073
  • Synonyms:Captopril (200 mg);Captopril Cardiovascular;(S)-(-)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S)-(-)-1-(3-Mercapto-2-methylpropionyl)-L-proline;3-Mercapto-2-Methylpropanoic acid 1,2-diphenylethylaMine salt (MMPA);CAPTOPRIL(RG);Captopril (Capoten);(S)-1-((S)-3-mercapto-2-methylpropanoyl)pyrrolidine-2-carboxylic acid;Captopril for system suitability
Price11 Properties Safety Information Description
11 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 1G
  • 5gm
  • 5G
  • 25gm
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberC1580
  • Product descriptionCaptopril
  • Packaging5G
  • Price₹8900
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC1580
  • Product descriptionCaptopril
  • Packaging25G
  • Price₹13700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number211875
  • Product descriptionCaptopril - CAS 62571-86-2 - Calbiochem An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC??= 23-35 nM) and acts as a reversible and competitive inh
  • Packaging1G
  • Price₹7070
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC8856
  • Product descriptionCaptopril meets USP testing specifications
  • Packaging1G
  • Price₹7480.08
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1307
  • Product descriptionCaptopril Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹8107.93
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC8856
  • Product descriptionCaptopril meets USP testing specifications
  • Packaging5G
  • Price₹18803.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4042
  • Product descriptionCaptopril ≥98% (HPLC), powder
  • Packaging5G
  • Price₹22169.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC8856
  • Product descriptionCaptopril meets USP testing specifications
  • Packaging25G
  • Price₹63261.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4042
  • Product descriptionCaptopril ≥98% (HPLC), powder
  • Packaging25G
  • Price₹74097.13
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number C 6151
  • Product descriptionCaptopril powder, ≥98% (HPLC)
  • Packaging5gm
  • Price₹18801
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number C 6151
  • Product descriptionCaptopril powder, ≥98% (HPLC)
  • Packaging25gm
  • Price₹62901
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C1580 Captopril 5G ₹8900 2022-05-26 Buy
TCI Chemicals (India) C1580 Captopril 25G ₹13700 2022-05-26 Buy
Sigma-Aldrich(India) 211875 Captopril - CAS 62571-86-2 - Calbiochem An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC??= 23-35 nM) and acts as a reversible and competitive inh 1G ₹7070 2022-06-14 Buy
Sigma-Aldrich(India) C8856 Captopril meets USP testing specifications 1G ₹7480.08 2022-06-14 Buy
Sigma-Aldrich(India) PHR1307 Captopril Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹8107.93 2022-06-14 Buy
Sigma-Aldrich(India) C8856 Captopril meets USP testing specifications 5G ₹18803.03 2022-06-14 Buy
Sigma-Aldrich(India) C4042 Captopril ≥98% (HPLC), powder 5G ₹22169.6 2022-06-14 Buy
Sigma-Aldrich(India) C8856 Captopril meets USP testing specifications 25G ₹63261.3 2022-06-14 Buy
Sigma-Aldrich(India) C4042 Captopril ≥98% (HPLC), powder 25G ₹74097.13 2022-06-14 Buy
ottokemi C 6151 Captopril powder, ≥98% (HPLC) 5gm ₹18801 2022-05-26 Buy
ottokemi C 6151 Captopril powder, ≥98% (HPLC) 25gm ₹62901 2022-05-26 Buy

Properties

Melting point :104-108 °C (lit.)
Boiling point :427.0±40.0 °C(Predicted)
alpha :-129.5 º (c=1, EtOH)
Density :1.2447 (rough estimate)
refractive index :-127.5 ° (C=1.7, EtOH)
storage temp. :room temp
solubility :H2O: 0.1 g/mL, very slightly hazy, colorless
form :Crystalline Powder
pka :3.7, 9.8(at 25℃)
color :white to off-white
Water Solubility :soluble
Merck :14,1774
BRN :477887
BCS Class :3
Stability :Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference :62571-86-2(CAS DataBase Reference)
NIST Chemistry Reference :Captopril(62571-86-2)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. As the first nonpeptidic ACE inhibitor to be developed (IC50 = 6.3 nM), captopril was discovered based on bradykinin-potentiating peptides isolated from the venom of B. Jararaca, a pit viper native to Brazil. It does not exhibit a domain preference for binding either the C- or N-terminal active sites of the somatic form of ACE, which may account for some of captopril’s negative side effects. Captopril is also a competitive and reversible inhibitor of leukotriene (LTA4) hydrolase, which results in the disruption of LTB4 synthesis at an IC50 value of 14 μM.

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