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ChemicalBook > Product Catalogue >API >Digestive system drugs >Antacid and Mucosal protective Drugs >Carbenoxolone disodium

Carbenoxolone disodium

Carbenoxolone disodium Structure
  • ₹4319.18 - ₹13433.83
  • Product name: Carbenoxolone disodium
  • CAS: 7421-40-1
  • MF: C34H48Na2O7
  • MW: 614.72
  • EINECS:231-044-0
  • MDL Number:MFCD03840711
  • Synonyms:(3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID 3-HEMISUCCINATE) DISODIUM SALT;CARBENOXOLONE DISODIUM SALT;CARBENOXOLONE SODIUM;18-beta-glycyrrhetinicacidhydrogensuccinate,disodiumsalt ;20-beta)-3-bet ;3-beta-hydroxy-11-oxoolean-12-en-30-oicacidhydrogensuccinate,disodiumsal ;3-o-(beta-carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oicacid,disodium ;disodiumglycyrrhetinylsuccina
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1G
  • 5G
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4790
  • Product descriptionCarbenoxolone disodium salt ≥98%
  • Packaging1G
  • Price₹4319.18
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4790
  • Product descriptionCarbenoxolone disodium salt ≥98%
  • Packaging5G
  • Price₹13433.83
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C4790 Carbenoxolone disodium salt ≥98% 1G ₹4319.18 2022-06-14 Buy
Sigma-Aldrich(India) C4790 Carbenoxolone disodium salt ≥98% 5G ₹13433.83 2022-06-14 Buy

Properties

Melting point :>275°C (dec.)
storage temp. :2-8°C
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
pka :pKa1 4.18; pKa2 5.52(at 25℃)
color :White to Off-White
Water Solubility :Soluble in water to 100 mM.
Stability :Hygroscopic
LogP :7.083 (est)
CAS DataBase Reference :7421-40-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Carbenoxolone is a derivative of β-glycyrrhetinic acid , a major metabolite of glycyrrhizin, one of the main constituents of licorice. Similar to β-glycyrrhetinic acid and glycyrrhizin, carbenoxolone has been shown to exhibit anti-ulcerative and anti-inflammatory properties. Carbenoxolone inhibits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; ) conversion of cortisol to cortisone, which contributes to its potential to induce mineralocorticoid hypertension. It is also reported to inhibit 11β-HSD2 conversion of cortisone to cortisol resulting in improved cognitive and neuroprotective effects.

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