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ChemicalBook > Product Catalogue >Food Additives >Sweeteners >18β-Glycyrrhetinic Acid

18β-Glycyrrhetinic Acid

18β-Glycyrrhetinic Acid Structure
  • ₹2300 - ₹19052
  • Product name: 18β-Glycyrrhetinic Acid
  • CAS: 471-53-4
  • MF: C30H46O4
  • MW: 470.69
  • EINECS:207-444-6
  • MDL Number:MFCD00003706
  • Synonyms:Enoxolone, 3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid;Aloe Vera, Freeze Dried Powder;18-β-Glycyrrhetinic acid, 98+%;18-beta-glycyrrheticacid ;Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3b,20b)-;(20S)-3β-Hydroxy-11-oxo-5α-olean-12-en-29-oic acid;GLYCYRRHETINIC ACID, 18B-(P);Glycyrrhetinic acid ,98%
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1G
  • 10G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberG0149
  • Product descriptionGlycyrrhetic Acid
  • Packaging1G
  • Price₹2300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberG0149
  • Product descriptionGlycyrrhetic Acid
  • Packaging25G
  • Price₹10700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG10105
  • Product description18β-Glycyrrhetinic acid 97%
  • Packaging10G
  • Price₹15458.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG10105
  • Product description18β-Glycyrrhetinic acid 97%
  • Packaging25G
  • Price₹19052
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) G0149 Glycyrrhetic Acid 1G ₹2300 2022-05-26 Buy
TCI Chemicals (India) G0149 Glycyrrhetic Acid 25G ₹10700 2022-05-26 Buy
Sigma-Aldrich(India) G10105 18β-Glycyrrhetinic acid 97% 10G ₹15458.1 2022-06-14 Buy
Sigma-Aldrich(India) G10105 18β-Glycyrrhetinic acid 97% 25G ₹19052 2022-06-14 Buy

Properties

Melting point :292-295 °C(lit.)
alpha :165 º (c=1, CHCl3,on dry ba)
Boiling point :492.11°C (rough estimate)
Density :0.9967 (rough estimate)
vapor pressure :10-220Pa at 20-50℃
refractive index :162 ° (C=1, MeOH)
storage temp. :2-8°C
solubility :Practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride.
pka :pKa 5.56±0.1 (Uncertain)
form :Crystalline Powder
color :White to off-white
optical activity :[α]22/D +170.0°, c = 1 in chloroform
Water Solubility :SOLUBLE IN ACETIC ACID
Merck :14,3590
BRN :2229654
LogP :4.5 at 20℃
CAS DataBase Reference :471-53-4(CAS DataBase Reference)
EPA Substance Registry System :Enoxolone (471-53-4)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

β-Glycyrrhetinic acid is a major metabolite of glycyrrhizin, one of the main constituents of licorice. Both β-glycyrrhetinic acid and glycyrrhizin have been shown to exhibit antiulcerative, anti-inflammatory, and immunomodulatory properties. β-Glycyrrhetinic acid is an inhibitor of the complement pathway (IC50 = 35 μM). At 100 mg/kg/day, β-glycyrrhetinic acid is protective against diabetes complications by reducing lipid peroxidation and increasing antioxidant activity in diabetic rats. β-Glycyrrhetinic acid inhibits mammalian DNA polymerases α, γ, κ, and λ with IC50 values of 16.1, 19.3, 15.8, and 13.7 μM, respectively. At 100-200 μM, β-glycyrrhetinic acid suppresses LPS-induced TNF-α production and NF-κB activation in mouse macrophages.

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