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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Peripheral vasodilators >Carvedilol

Carvedilol

Carvedilol Structure
  • ₹9093 - ₹43668.05
  • Product name: Carvedilol
  • CAS: 72956-09-3
  • MF: C24H26N2O4
  • MW: 406.47
  • EINECS:1308068-626-2
  • MDL Number:MFCD00864692
  • Synonyms:1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL;CARVEDILOL;DIMITONE;DQ-2466;DILATREND;BM-14190;1-(9h-carbozol-4-yloxy)-3-[[2-(2-methoxy phenoxy)ethyl] amino]-2-propanol;1(9H-CARBAZOL-4-YLOXY)-3-[[(2-(2-METHOXYPHENOXY)ETHYL]AMINO]-2-PROPANOL (CARVEDILOL)
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 50MG
  • 250MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1265
  • Product descriptionCarvedilol Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹9093
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3993
  • Product descriptionCarvedilol ≥98% (HPLC), solid
  • Packaging50MG
  • Price₹10240.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC3993
  • Product descriptionCarvedilol ≥98% (HPLC), solid
  • Packaging250MG
  • Price₹43668.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PHR1265 Carvedilol Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹9093 2022-06-14 Buy
Sigma-Aldrich(India) C3993 Carvedilol ≥98% (HPLC), solid 50MG ₹10240.45 2022-06-14 Buy
Sigma-Aldrich(India) C3993 Carvedilol ≥98% (HPLC), solid 250MG ₹43668.05 2022-06-14 Buy

Properties

Melting point :113-117°C
Boiling point :655.2±55.0 °C(Predicted)
Density :1.250±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
pka :13.90±0.20(Predicted)
form :solid
color :white to off-white
Water Solubility :449.2ug/L(22.5 ºC)
Merck :14,1873
CAS DataBase Reference :72956-09-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Carvedilol is a non-selective β-antagonist with α1-adrenolytic activity that binds the α1-, α2-, and β1-adrenoceptors with Ki values of 2.2 nM, 3.4 μM, and 0.81 nM, respectively. By inhibiting excess stimulation of catecholamine it demonstrates antiarrhythmic activity in a rat model of adrenaline-induced arrhythmia with an ED50 value of 0.25 mg/kg. Carvedilol has also been shown to activate cardioprotective signaling through β-arrestin and ERK1/2 activation (EC50 = 2 nM).

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Jigs Chemical ltd Cadila Pharmaceuticals Ltd Chemicea Pharmaceuticals Pvt Ltd S.V ENTERPRISES SNECOFRi Pvt Ltd GLP Pharma Standards Gonane Pharma CHEMAZON LABORATORIES Aurobindo Pharma Limited Viyash Life Sciences Pvt Ltd