Cereblon Ligand 1
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- Product name: Cereblon Ligand 1
- CAS: 1061605-21-7
- MF: C15H12N2O7
- MW: 332.27
- EINECS:
- MDL Number:MFCD31560477
- Synonyms:Cereblon Ligand 1;2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid;Cereblon ligand 3;Pomalidomide Related Compound 1;Thalidomide-Acid;Acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-;2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetic acid;Thalidomide-4-hydroxyacetate
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Properties
Boiling point :660.5±55.0 °C(Predicted)
Density :1.606±0.06 g/cm3(Predicted)
solubility :Soluble in DCM
form :A crystalline solid
pka :2.95±0.10(Predicted)
color :White to off-white
InChI :InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)
InChIKey :ZVWIXIGBWIEDFO-UHFFFAOYSA-N
SMILES :C(O)(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
Density :1.606±0.06 g/cm3(Predicted)
solubility :Soluble in DCM
form :A crystalline solid
pka :2.95±0.10(Predicted)
color :White to off-white
InChI :InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)
InChIKey :ZVWIXIGBWIEDFO-UHFFFAOYSA-N
SMILES :C(O)(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
Safety Information
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Description
Thalidomide-Acid (Cereblon Ligand 1) is a linker of Thalidomide which is commonly used as a precursor to PROTAC that hijacks cereblon as the E3 ubiquitin ligase component.More related product prices
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate